Evidence map›Paper›PMID 41238190›Full record

ArticleJournal of lipid research2025

HSD17β11 regulates PLIN5-ATGL mediated lipolysis, but not hepatic lipid metabolism in mice.

Stacey N Keenan, Natasha D Suriani, Gio Fidelito, Jackie Bayliss, Jieqiong Lou, Ashleigh N Solano, Joanna Sacharz, David A Stroud, Ayenachew Bezawork-Geleta, Geraldine Ooi and 3 more

Abstract read
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In one paragraph

Article in Journal of lipid research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Stacey N KeenanDepartment of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia.
Natasha D SurianiDepartment of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia.
Gio FidelitoDepartment of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia.
Jackie BaylissDepartment of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia.
Jieqiong LouSchool of Physics, University of Melbourne, Melbourne, Victoria, Australia; Department of Biochemistry and Pharmacology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, Melbourne, Victoria, Australia.
Ashleigh N SolanoSchool of Physics, University of Melbourne, Melbourne, Victoria, Australia; Department of Biochemistry and Pharmacology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, Melbourne, Victoria, Australia.
Joanna SacharzDepartment of Biochemistry and Pharmacology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, Melbourne, Victoria, Australia.
David A StroudDepartment of Biochemistry and Pharmacology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, Melbourne, Victoria, Australia; Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Victorian Clinical Genetics Services, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Ayenachew Bezawork-GeletaDepartment of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia.
Geraldine OoiDepartment of Surgery, School of Translational Medicine, Monash University, Bariatric Unit, Department of General Surgery, The Alfred Hospital, Melbourne, Victoria, Australia.
Paul R BurtonDepartment of Surgery, School of Translational Medicine, Monash University, Bariatric Unit, Department of General Surgery, The Alfred Hospital, Melbourne, Victoria, Australia.
Elizabeth HindeSchool of Physics, University of Melbourne, Melbourne, Victoria, Australia; Department of Biochemistry and Pharmacology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, Melbourne, Victoria, Australia.
Matthew J WattDepartment of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia. Electronic address: matt.watt@unimelb.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydroxysteroid 17β dehydrogenase 11 (HSD17β11) is a member of the 17β-HSD family with canonical roles in steroid metabolism. Given its predominant localization on lipid droplets, we investigated HSD17β11's role in lipid metabolism. In patients with metabolic dysfunction-associated fatty liver disease (MASLD), liver HSD17β11 levels are reduced, correlating with liver steatosis severity. HSD17β11 deletion in human cell lines increased lipid droplet size and number. This is associated with triglyceride accumulation due to impaired lipolysis and increased fatty acid uptake. Mechanistically, HSD17β11 facilitates the interaction between PLIN5 and ATGL, enabling efficient protein kinase A (PKA)-stimulated lipolysis. Surprisingly, Hsd17β11 deletion did not affect liver lipid metabolism or MASLD development in lean or obese mice. These findings demonstrate that while HSD17β11 is crucial for efficient PKA-mediated lipolysis in human cells, its deficiency appears redundant for lipid metabolism in mice.

Indexed as

17-Hydroxysteroid DehydrogenasesLipaseLipid MetabolismLipolysisLiverPerilipin-5AnimalsCyclic AMP-Dependent Protein KinasesFatty LiverHumansMaleMiceMice, Inbred C57BL17-Hydroxysteroid DehydrogenasesCyclic AMP-Dependent Protein KinasesLipasePerilipin-5Plin5 protein, mouselipid dropletlipid metabolismlipolysismetabolic dysfunction-associated steatotic liver diseasephosphorylationPKA

Identifiers

PMID41238190
PMCPMC12743511

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.