ArticleNature communications2025
Cortical hierarchy underlying homeostatic sleep pressure alleviation.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Central nervous system lymphatic network: from the maintenance of brain homeostasis to emerging therapeutic perspectives in neurodegenerative diseases.Translational neurodegeneration · 2026Review
- Mapping shared and specific cortical after-effects of repetitive TMS on brain function.BMC medicine · 2026Article
- A unified time-frequency foundation model for sleep decoding.Nature communications · 2026Article
- Cortical hierarchy underlying homeostatic sleep pressure alleviation.Nature communications · 2025Article
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Authors and funding
16 authors.
Funding
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Abstract
Sleep dissipates accumulated sleep pressure and restores brain function, yet how this recovery unfolds across the cortical hierarchy remains unclear. Here, we record simultaneous electroencephalogram (EEG) and blood oxygen level-dependent (BOLD) functional magnetic resonance imaging data from 130 healthy adults to map spatial patterns underlying sleep pressure alleviation. Compared to wakefulness, sleep elicits spatially heterogeneous changes in BOLD fluctuation along a sensory-association cortical gradient. The magnitude of these sleep-wake differences correlates with individual slow-wave activity and is most pronounced during the first hour of sleep. As slow waves dissipates, these hierarchical differences are progressively downscaled, implicating homeostatic regulation in sculpting cortical plasticity. In addition, the homeostatic regulation of BOLD fluctuation amplitude is spatially associated with the regional distribution of glycolysis. Finally, recovery sleep reinstates hierarchical BOLD dynamics after sleep loss in an independent sleep deprivation study. These findings consistently suggest a cortical hierarchy underlying the dynamic changes in sleep homeostasis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.