Evidence map›Paper›PMID 41238564›Full record

ArticleCell death & disease2025

Uncomplexed-TSC1 deploys novel mTORC1-independent pathway to exacerbate the liver glycogen storage in TSC.

Xiaoqiao Yue, Yanping Zhang, Na Zhao, Tao Lang, Guangxin Chen, Qiuhong Xiong, Lei Gao, Wenjing Wang, Ping Li, Changxin Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaoqiao YueInstitutes of Biomedical Sciences, Shanxi University, Taiyuan, China.
Yanping ZhangInstitutes of Biomedical Sciences, Shanxi University, Taiyuan, China.
Na ZhaoDepartment of Pathology, The Second Hospital of Shanxi Medical University, Taiyuan, China.ORCID http://orcid.org/0000-0003-0472-5909
Tao LangInstitutes of Biomedical Sciences, Shanxi University, Taiyuan, China.
Guangxin ChenInstitutes of Biomedical Sciences, Shanxi University, Taiyuan, China.
Qiuhong XiongInstitutes of Biomedical Sciences, Shanxi University, Taiyuan, China.
Lei GaoInstitutes of Biomedical Sciences, Shanxi University, Taiyuan, China.
Wenjing WangSchool of Medicine, Nankai University, Tianjin, China.
Ping LiInstitutes of Biomedical Sciences, Shanxi University, Taiyuan, China. pingli@sxu.edu.cn.ORCID http://orcid.org/0000-0002-6137-6154
Changxin WuInstitutes of Biomedical Sciences, Shanxi University, Taiyuan, China. cxw20@sxu.edu.cn.ORCID http://orcid.org/0000-0002-7416-1662

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82070691
6 · The paper itself

Abstract

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by inactivating mutations in TSC1 or TSC2 gene, leading to mTORC1 hyperactivation. However, mTORC1-independent mechanisms in this disorder remain poorly understood. In the study, excess glycogen storage was found in Tsc1

Indexed as

LiverLiver GlycogenMechanistic Target of Rapamycin Complex 1Tuberous SclerosisTuberous Sclerosis Complex 1 ProteinAnimalsHumansMiceSignal TransductionTuberous Sclerosis Complex 2 ProteinLiver GlycogenMechanistic Target of Rapamycin Complex 1Tsc1 protein, mouseTSC2 protein, humanTsc2 protein, mouseTuberous Sclerosis Complex 1 ProteinTuberous Sclerosis Complex 2 Protein

Identifiers

PMID41238564
PMCPMC12618697

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.