Trial reportScientific reports2025
Effects of TENS with home exercise improve pain and muscle strength in older adults with pre-radiographic to mild knee osteoarthritis.
Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Review
- A narrative review of clinical research on knee osteoarthritis in 2025.Annals of joint · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To date, no large-scale studies have been conducted on pre-radiographic to mild cases of knee osteoarthritis. Therefore, this randomized, double-masked, sham-controlled trial investigated the effects of transcutaneous electrical nerve stimulation (TENS) combined with home exercise in older individuals with pre-radiographic to mild knee osteoarthritis (Kellgren-Lawrence grade ≤ 2). A total of 126 participants experiencing knee pain were randomly assigned to the TENS (n = 64) or sham TENS group (n = 62), both combined with home exercise. The main outcome was knee pain during activity, measured via a visual analog scale (VAS). Both groups showed significantly decreased VAS scores during activity, with greater reductions in the TENS group than in the sham TENS group. Compared with the sham TENS group, the TENS group also showed significantly increased knee extensor strength in the painful knee, with no changes in the non-painful knee. No significant changes were observed in gait ability, physical activities, activities of daily living, and mental health between the groups. In conclusion, TENS combined with home exercise can reduce knee pain and increase knee extensor strength in older individuals with pre-radiographic to mild knee osteoarthritis.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.