Evidence map›Paper›PMID 41238664›Full record

ArticleNPJ science of food2025

Comparative study of rebaudioside A and rebaudioside Aα: physicochemical properties and in vivo metabolism.

Hye-Jin Kim, Hye-Jin Kang, Sangyi Lim, Ok Cheol Kim, Ki-Nam Yoon, Junhyeong Lee, Merc Emil Matienzo, Min-Jung Park, Bu-Soo Park, Jeong-Yong Cho and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ science of food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The progress on stevia (Frontiers in nutrition · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hye-Jin Kim *Department of Integrative Food, Bioscience and Biotechnology, Graduate School of Chonnam National University, Gwangju, South Korea.
Hye-Jin Kang *Research Institute of Agricultural Science and Technology, Chonnam National University, Gwangju, South Korea.
Sangyi Lim *Department of Veterinary Physiology, College of Veterinary Medicine, Chonnam National University, Gwangju, South Korea.
Ok Cheol KimDepartment of Integrative Food, Bioscience and Biotechnology, Graduate School of Chonnam National University, Gwangju, South Korea.
Ki-Nam YoonResearch Institute of Agricultural Science and Technology, Chonnam National University, Gwangju, South Korea.
Junhyeong LeeDepartment of Veterinary Physiology, College of Veterinary Medicine, Chonnam National University, Gwangju, South Korea.
Merc Emil MatienzoDepartment of Veterinary Physiology, College of Veterinary Medicine, Chonnam National University, Gwangju, South Korea.
Min-Jung ParkDepartment of Veterinary Physiology, College of Veterinary Medicine, Chonnam National University, Gwangju, South Korea.
Bu-Soo ParkFood Biotech R&D Center, Samyang Corp., Seongnam-si, Gyeonggi-do, South Korea.
Jeong-Yong ChoDepartment of Integrative Food, Bioscience and Biotechnology, Graduate School of Chonnam National University, Gwangju, South Korea.
Seong-Jin HongResearch Institute of Agricultural Science and Technology, Chonnam National University, Gwangju, South Korea. hong0624243@naver.com.
Dong-Il KimDepartment of Veterinary Physiology, College of Veterinary Medicine, Chonnam National University, Gwangju, South Korea. kimdi@chonnam.ac.kr.
Young-Min KimDepartment of Integrative Food, Bioscience and Biotechnology, Graduate School of Chonnam National University, Gwangju, South Korea. u9897854@jnu.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stevioside (ST) and rebaudioside A (Reb A) are 250 times sweeter than sucrose, but their bitterness and low water solubility limit their application. Rebaudioside Aα (Reb Aα) was synthesized using dextransucrase. Reb Aα exhibited 80-fold greater water solubility and lower thermal mass loss than Reb A and had melting point >180 °C. Reb Aα was stable within pH range 1.4-10 and exhibited excellent storage stability in aqueous solution. In vitro digestion revealed that Reb Aα was hydrolyzed into ST and glucose. In vivo, Reb Aα administration did not affect body weight gain, glucose tolerance, energy homeostasis, or liver histology. Also, in the Reb Aα group, inflammatory crown-like structures were not observed in white adipose tissue and uncoupling protein 1 was significantly upregulated in brown adipose tissue. Gut microbiota analysis revealed no significant differences in microbial composition between the control and Reb A or Reb Aα groups.

Identifiers

PMID41238664
PMCPMC12618661

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.