Evidence map›Paper›PMID 41238957›Full record

ArticleActa parasitologica2025

Therapeutic Effect of Allium sativum (Garlic) Extract Using Nanotechnology on Murine Chronic Toxoplasmosis.

Doaa Abdulfttah Ahmad Amer, Fatma Mohamad El-Lessy, Ashraf M Barakat, Rehab Mohamed El Shahat, Sabry A Sadek, Reda M Abdelhameed, Mona Mohammed Elderbawy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta parasitologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Antimicrobial Activity of Zinc Oxide Nanoparticles andThe East African health research journal · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Doaa Abdulfttah Ahmad AmerDepartment of Parasitology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Fatma Mohamad El-LessyDepartment of Parasitology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Ashraf M BarakatDepartment of Zoonotic Diseases, National Research Centre, Giza, Egypt.
Rehab Mohamed El ShahatDepartment of Pharmacology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Sabry A SadekDepartment of Zoonotic Diseases, National Research Centre, Giza, Egypt.
Reda M AbdelhameedApplied Organic Chemistry Department, National Research Centre, Chemical Industries Research Institute, Giza, Egypt.
Mona Mohammed ElderbawyDepartment of Parasitology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt. dr_monagyobs@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCurrent treatments for toxoplasmosis are often limited. This study aimed to assess the therapeutic efficacy of Allium sativum (garlic) extract loaded onto Fe-MOFs in a murine model of chronic toxoplasmosis.

methodsSixty-five mice were assigned to seven groups. All groups, except the healthy control (GI), were infected with the Toxoplasma gondii ME49 strain. Treatments included Fe-MOFs (GIII), spiramycin (GIV), spiramycin@Fe-MOFs (GV), garlic extract (GVI), and garlic extract@Fe-MOFs (GVII). In vitro drug toxicity for garlic, Fe-MOFs, and garlic extract@Fe-MOFs were detected. Brain cysts counted, histopathological changes in various organs, and parasite DNA load (P29 gene) were assessed post-treatment using real-time PCR.

resultsSpiramycin@Fe-MOFs (GV) and garlic extract @Fe-MOFs (GVII) groups showed a significant reduction in brain cyst burden (39.63% and 59.45%, respectively), along with marked improvement in histopathological changes compared to the other treated infected groups.

conclusionThese findings support garlic@Fe-MOFs as a potential treatment for toxoplasmosis, demonstrating enhanced efficacy, reduced toxicity, and improved histopathological outcomes.

Indexed as

Antiprotozoal AgentsGarlicPlant ExtractsToxoplasmosis, AnimalAnimalsBrainChronic DiseaseDisease Models, AnimalFemaleMiceNanotechnologyToxoplasmaAntiprotozoal AgentsPlant ExtractsAllium SativumGarlicNanoparticlesToxoplasmosis

Identifiers

PMID41238957
PMCPMC12618351

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.