Evidence map›Paper›PMID 41239111›Full record

ArticleGeroScience2025

Targeted clearance of senescent cells alleviates alcohol-associated liver disease by restoring cellular function and immune balance.

Tian Tian, Yuhua Xue, Zhewei Song, Brady Jin-Smith, Joshua Barkin, Melak Ottallah, Mahfuza Mannan, Arina Zhirkova, Daohong Zhou, Liya Pi

Abstract read
PubMed Publisher
In one paragraph

Article in GeroScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tian Tian *Department of Pathology, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
Yuhua Xue *Department of Pathology, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
Zhewei SongDepartment of Pathology, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
Brady Jin-SmithDepartment of Pathology, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
Joshua BarkinDepartment of Pathology, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
Melak OttallahDepartment of Pathology, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
Mahfuza MannanDepartment of Pathology, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
Arina ZhirkovaDepartment of Pathology, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
Daohong ZhouDepartment of Biochemistry and Structural Biology, University of Texas Health Science Center, Houston, TX, 77030, USA.
Liya PiDepartment of Pathology, Tulane University School of Medicine, New Orleans, LA, 70112, USA. lpi@tulane.edu.ORCID http://orcid.org/0000-0002-9868-7677

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The liver is one of the organs most affected by alcohol consumption, and its interaction with aging is particularly significant. Chronic alcohol consumption accelerates liver aging through mechanisms such as oxidative stress, inflammation, fibrosis, and impaired regeneration. It is still unknown whether senescent cell clearance orchestrates innate and adaptive immune responses during the alcohol-induced old liver damage process. To investigate this, we used INK-ATTAC transgenic mice treat with AP20187 (AP) to eliminate p16

Indexed as

Alcohol-associated liver diseaseAP20187ImmunosenescenceINK-ATTAC transgenic miceSenescent

Identifiers

PMID41239111

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.