ArticleAAPS PharmSciTech2025
A Self-healable Hydrogel for Co-delivery of Hot-Melt Extruded System With Curcumin and Hesperetin Intended for Topical Application.
Article in AAPS PharmSciTech, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The trial behind it
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Who cites it
1 citing paper in PubMed.
- Self-healing hydrogels: mechanisms and applications in biomedical and environmental fields.Biodegradation · 2026Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hot-melt extrusion is an effective method for enhancing the solubility of weakly water-soluble compounds through amorphization, but the obtained powder form does not provide sufficient skin adherence or residence time, thus requiring incorporation into a suitable carrier for topical delivery. Hydrogels can serve as an appropriate carriers for such systems, offering additional characteristics such as self-healing and pH-responsiveness. Therefore, our research aimed to develop a hydrogel carrier with distinct features for a hot-melt extruded system containing curcumin and hesperetin, both having anti-cancer activity against skin cancer. We used a double cross-linking method with tannic acid and aluminum ions to prepare three hydrogels with different ratio of these agents, characterized by ATR-FTIR and rheological tests. Swelling studies in buffers of varying pH and in vitro release tests in pH 5.5 showed significant pH-responsive swelling and varying release rates of active compounds, influenced by cross-linking degrees. The prepared hydrogels swelled significantly, with percentages ranging from 170 to 4016%, with the maximum swelling at pH 5.5. Hesperetin release was measured as 84.92 ± 0.03%, 84.21 ± 1.21%, and 80.75 ± 2.76% in formulations H0, H1, and H2, respectively. While the release rate of curcumin increased with the degree of cross-linking, reaching 9.03 ± 0.07%, 26.43 ± 1.16%, and 27.31 ± 2.51%, respectively. In addition, a qualitative analysis with optical microscope confirmed the produced hydrogel's self-healing characteristics. Our findings provide a novel approach to improve the co-delivery of amorphous curcumin and hesperetin compounds to the skin.
Indexed as
Identifiers
41239144What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.