Observational studyBMC oral health2025
Interaction between methylated arginine metabolites and oxidative stress in periodontitis: a cross-sectional study.
Observational study in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06973148 (Evaluation of Oxidative Stress and Methylated Arginine Levels in Individuals With Periodontitis), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Oxidative Stress and Methylated Arginine Levels in Individuals With Periodontitis
Who cites it
2 citing papers in PubMed.
- Mitochondrial hub: the integrative axis connecting ferroptosis and metabolic reprogramming in periodontitis.Molecular biology reports · 2026Review
- Bridging systems: oral-kidney connections - pathophysiological links, clinical implications, and health system integration - a narrative review.BMC nephrology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPeriodontitis is a chronic inflammatory disease associated with systemic conditions such as endothelial dysfunction. Nitric oxide (NO) plays a central role in inflammation and oxidative stress, both of which are critical in periodontal pathogenesis. Arginine (Arg) is the precursor of NO, while its methylated derivatives, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), inhibit NO synthesis. This study investigated the interplay between NO metabolism and oxidative stress in periodontitis. MATERIALS AND
methodsA cross-sectional study was conducted with 20 patients with periodontitis and 20 healthy controls. Clinical periodontal assessments were performed, and salivary and serum levels of the oxidative stress index (OSI), ADMA, SDMA, and arginine were measured using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS). Statistical significance was set at p < 0.05.
resultsGroups did not differ by age or sex (p = 0.053 and p = 0.507). Clinical periodontal parameters were significantly higher in the periodontitis group (p < 0.001). Salivary OSI, ADMA, SDMA, and Arg were significantly elevated in periodontitis patients (p = 0.026, p = 0.002, p = 0.006, and p < 0.001), while serum SDMA levels were reduced (p = 0.026). Salivary OSI, ADMA, and Arg correlated positively with all clinical periodontal parameters (p < 0.05). Salivary SDMA correlated with probing depth (r = 0.329, p = 0.039), and strong associations were observed between salivary ADMA and SDMA (r = 0.722, p < 0.001) and between serum ADMA and Arg (r = 0.461, p = 0.003).
conclusionThis study underscores the complex interplay between NO metabolism, oxidative stress, and inflammation in periodontitis, suggesting that ADMA- and SDMA-mediated disruption of Arg metabolism may exacerbate oxidative stress and inflammation, worsening the disease. CLINICAL RELEVANCE: This study provides insights into the interplay between NO metabolism and oxidative stress in periodontitis, emphasizing the potential role of ADMA and SDMA in disease progression. Understanding these mechanisms may contribute to a better comprehension of the systemic impact of periodontitis.
trial registrationThe trial protocol was retrospectively registered at ClinicalTrials.gov (ID: NCT06973148) on April 28, 2025.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.