Observational studyJournal of ovarian research2025
Influence of COVID-19 on endocrine and metabolic profiles in women with pathological ovarian aging.
Observational study in Journal of ovarian research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- COVID-19 and female reproductive health: pathophysiological mechanisms and clinical reproductive outcomes.Frontiers in medicine · 2026Review
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Authors and funding
13 authors.
Funding
Abstract
backgroundNumerous studies have explored the impact of coronavirus disease 2019 (COVID-19) on endocrine and metabolic functions, yet research targeting the population with pathological ovarian aging (POA) remains scarce. The aim of our study was therefore to explore the influence of COVID-19 on ovarian function, thyroid function, liver function, and lipid profiles in women with POA.
designNested, self-controlled study.
resultsThis is an observational self-controlled study. 141 women diagnosed with COVID-19 during the study period were recruited from the prospective Chinese Ovarian Aging Cohort (COACH). After being infected with COVID-19, patients with POA presented further reproductive hormone dysregulation as evaluated by significantly decreased estradiol (E2) (22.4 [IQR 7.8-62.1] pg/mL vs. 16.9 [IQR 6.2-51.9] pg/mL, P = 0.034) and inhibin B (INHB) (16.3 [IQR 10.0-23.6] pg/mL vs. 12.3 [IQR 10.0-21.0] pg/mL, P = 0.029) concentrations. In addition, patients with POA may experience thyroid dysfunction, liver dysfunction, and lipid metabolism disorders after SARS-CoV-2 infection, as indicated by significantly decreased triiodothyronine (FT3) levels, and significantly increased aspartate transaminase (AST) and total cholesterol (TC) levels (all P < 0.05). We performed subgroup analyses stratified by age to determine whether POA patients of different age groups exhibit different endocrine and metabolic responses to SARS-CoV-2 infection. The levels of E2 (25.5 [IQR 9.3-77.6] pg/mL vs. 14.6 [IQR 5.1-37.9] pg/mL, P = 0.006) and INHB (16.9 [IQR 10.0-25.1] pg/mL vs. 10.7 [IQR 10.0-22.0] pg/mL, P = 0.012) were significantly decreased after SARS-CoV-2 infection in women younger than 35 years. In both subgroups, the level of FT3 was significantly decreased after SARS-CoV-2 infection, whereas the level of TC was significantly increased after SARS-CoV-2 infection, independent of age (all P < 0.05).
conclusionsThis study provides preliminary clinical evidence that patients with POA and confirmed SARS-CoV-2 infection may experience further reproductive hormone dysregulation, along with thyroid dysfunction, liver dysfunction, and lipid disorders, facilitating improved clinical management.
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