ArticleJournal of neuroinflammation2025
Pediococcus acidilactici attenuates chronic stress-induced depression via generating metabolite indole-3-lactic acid and downregulating neuroinflammation.
Article in Journal of neuroinflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Potential application of brain-gut axis-based treatments in Long COVID and ME/CFS: a case-based systematic review.Journal of translational medicine · 2026Pooled it
- Conjunctival Sac-Derived Lactobacillus mucosae MM-1 Metabolite Indole-3-Lactic Acid Attenuates Lens-Induced Myopia in Mice via AHR Activation and TGF-β/Smad Inhibition.Microbial biotechnology · 2026Article
- [Isolation and identification ofNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- Aspirin alleviates long-term high-fat diet-induced depressive-like behavior in male mice via suppressing arachidonic acid-mediated microglial activation and neuroinflammation.Molecular psychiatry · 2026Article
- The Effect of Pediococcus Lactis and Postbiotics on Gut Health and Intestinal Metabolic Profiles.Nutrients · 2026Article
- L-kynurenine reshapes immune microenvironment to alleviate methamphetamine-induced chronic lung injury through gut-lung axis.Microbiome · 2026Article
- Flos sophorae immaturus exosome-like nanovesicles alleviate ulcerative colitis by attenuating intestinal oxidative stress and inflammation through activating Aryl hydrocarbon receptor via gut microbiota and tryptophan metabolism regulation.Journal of nanobiotechnology · 2026Article
- Akkermansia muciniphila vesicles attenuate smoking-induced cognitive decline via ILA-mediated AhR-dependent microglial reprogramming.Journal of nanobiotechnology · 2026Article
- Assessment of the beneficial effects ofFrontiers in neuroscience · 2026Article
- Transcutaneous auricular vagus nerve stimulation improves depressive-like behaviors in CUMS rats through regulation of gut microbiome, serum metabolites, and immune factors.Frontiers in microbiology · 2026Article
- ExoBDNF Probiotic Supplementation Enhances Cognition in Subjective Cognitive Decline.Medicina (Kaunas, Lithuania) · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundDepression, a prevalent mental disorder worldwide, is associated with pathological mechanisms including neuroinflammation. Pediococcus acidilactici has shown the potential neuroprotective effects, yet its role in ameliorating depression and the underlying mechanisms remain unclear.
methodsEight-week-old male C57BL/6J mice were subjected to chronic unpredictable mild stress (CUMS) for 6 weeks to establish a depression model. Mice were orally administered Pediococcus acidilactici CGMCC 35671 (strain GOLDGUT-EZMind) (1 × 10
resultsPediococcus acidilactici CGMCC 35671 supplementation significantly ameliorated anxiety-like, depressive-like, and social interaction deficits in CUMS mice. Excessive microglial activation in the hippocampal dentate gyrus and cortex was suppressed, with reduced levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and elevated levels of the anti-inflammatory (IL-22) in the brain. Cortical neurotransmitter levels of serotonin and dopamine were increased, and serum oxidative stress markers were attenuated. Furthermore, P. acidilactici CGMCC 35671 supplementation elevated serum ILA concentrations and upregulated mRNA expression of AHR downstream markers (CYP1A1, CYP1A2, CYP1B1) in the brain. Conversely, AHR inhibitor administration abrogated the ameliorative effects of P. acidilactici CGMCC 35671 on neuroinflammation and depressive symptoms in CUMS mice.
conclusionPediococcus acidilactici CGMCC 35671 metabolizes tryptophan to produce ILA, which crosses the blood-brain barrier via systemic circulation to activate the AHR pathway, thereby attenuating neuroinflammation and ameliorating depressive symptoms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.