Evidence map›Paper›PMID 41239408›Full record

ReviewOrphanet journal of rare diseases2025

Animal models of methylmalonic acidemia: insights and challenges.

Shan Shan, Min Liu, Yue Ma, Meng Sun, Yue Wang, Hui Zou

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Orphanet journal of rare diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shan Shan *Medical Research Center, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, 250000, China.
Min Liu *Medical Research Center, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, 250000, China.
Yue MaSchool of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, China.
Meng SunNewborn Disease Screening Center, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, 250000, China.
Yue WangMedical Research Center, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, 250000, China. wangyue@sdfmu.edu.cn.ORCID 0000-0003-2090-275X
Hui ZouMedical Research Center, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, 250000, China. zouhui819@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methylmalonic acidemia (MMA) is a rare genetic disorder caused by disruptions in the metabolism of methylmalonic acid, resulting in severe neurological and systemic complications. Animal models have become indispensable in advancing our understanding of MMA pathogenesis, evaluating treatment options, and exploring new therapies. This review highlights recent advancements in MMA research, focusing on the characteristics, advantages, and limitations of various genetically engineered animal models, including murine and zebrafish models. By integrating insights from these models, this work aims to provide a foundation for future clinical applications and therapeutic innovations.Clinical trial number Not applicable.

Indexed as

Amino Acid Metabolism, Inborn ErrorsDisease Models, AnimalAnimalsHumansMethylmalonic AcidMiceZebrafishMethylmalonic AcidAnimal modelsInherited metabolic diseasesMethylmalonic acidemiaPathogenesisTherapeutic strategies

Identifiers

PMID41239408
PMCPMC12619279

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.