ArticleDiabetology & metabolic syndrome2025
Diagnostic performance of 1-hour plasma glucose and glucose curve shape during oral glucose tolerance test: a cross-sectional study in a Brazilian cohort.
Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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6 authors.
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Abstract
backgroundThe 1-h plasma glucose (1-h PG) during oral glucose tolerance test (OGTT) may enhance early dysglycemia detection compared with conventional markers. Distinct glucose curve morphologies correlate with glycemic profiles, insulin sensitivity, and β-cell function. We aimed to compare 1-h PG diagnostic performance with conventional methods and explored glucose curve morphology prevalence in a Brazilian population.
methodsThis retrospective cross-sectional study analyzed 1,797 OGTT records from a Brazilian laboratory (2021-2024). Glycemic profiles were classified using 1-h PG, fasting plasma glucose (FPG), 2-h PG, and HbA1c according to American Diabetes Association, Brazilian Diabetes Society and International Diabetes Federation criteria. Cohen's κ assessed inter-method agreement, McNemar's chi-square tests compared high glycemic risk detection and χ
resultsParticipants were predominantly female (68.9%; mean age 49.6 ± 15.0 years). The 1-h PG identified 27.8% more intermediate hyperglycemia (IH)/type 2 diabetes mellitus (T2DM) cases than FPG, 16.8% more than 2-h PG, and 26.7% more than HbA1c. The 1-h PG identified more individuals at high glycemic risk than FPG (χ
conclusionsThe 1-h PG thresholds ≥ 8.6 mmol/L (155 mg/dL) for IH and ≥ 11.6 mmol/L (209 mg/dL) for T2DM identified more dysglycemia cases than conventional methods, supporting early detection utility. Monophasic curve morphology was associated with impaired glycemic profiles, highlighting prognostic relevance.
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