ArticleJournal of ovarian research2025
Up-regulated WNT5A in PCOS affects steroidogenesis, proliferation and apoptosis of granulosa cells through the PI3K/AKT pathway.
Article in Journal of ovarian research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Oral Streptococcus salivarius Couples Neutrophil IRGM1 Signaling to NET Formation and Colorectal Cancer Metastasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Insulin resistance, inflammation, oxidative stress and dysregulated WNT/β-Catenin signaling in polycystic ovary syndrome: A review.Molecular biology reports · 2026Review
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Authors and funding
6 authors.
Funding
Abstract
backgroundPolycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine disorders in women of reproductive age and is characterized by a chronic state of excessive inflammation. Increased expression of WNT5A in a variety of diseases is thought to be related to inflammatory states. The purpose of this study was to explore the potential effects of WNT5A on ovarian granulosa cells and its potential role in the pathogenesis of PCOS.
resultsIn this study, we found increased expression of WNT5A in the follicular fluid and granulosa cells (GCs) of PCOS patients undergoing in vitro fertilization-embryo transfer (IVF-ET). By constructing an animal model of PCOS, we verified the elevated expression of WNT5A and decreased expression of CYP19A1, a key enzyme for steroidogenesis, in the ovarian granulosa cells of PCOS mice compared with those of controls. LPS stimulation induced significant upregulation of WNT5A expression in human ovarian granulosa tumor (KGN) cells. WNT5A can inhibit KGN cell proliferation and promote KGN cell apoptosis, and overexpression of WNT5A can inhibit the expression of genes related to steroidogenesis and steroid hormone secretion in vitro. WNT5A can activate the PI3K/AKT signalling pathway. A PI3K/AKT pathway inhibitor (LY-294002) inhibited the effects of WNT5A on key steroidogenesis genes in KGN cells.
conclusionsWNT5A inhibits steroidogenesis via the PI3K/AKT pathway in granulosa cells. Our findings suggest that increased WNT5A may be attributed to inflammation and may result in endocrine dysregulation in PCOS patients.
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