Evidence map›Paper›PMID 41239508›Full record

ArticleJournal of ovarian research2025

Selenium nanoparticles mitigate Cyclophosphamide-Induced premature ovarian failures in mice by activating PI3K/AKT signaling pathway and inhibiting ferroptosis.

Gang Liu, Lina Dai, Rongrong Zhang, Mengxuan Jia, Shuting Lan, Xiaomei Sun, Zhikang Wang, Yanfeng Dai, Shuwei Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ovarian research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gang Liu *Clinical Research Center, Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Hohhot, Inner Mongolia, 010030, China.ORCID http://orcid.org/0000-0002-5180-3765
Lina Dai *College of Basic Medicine, Inner Mongolia Medical University, No. 5 Xinhua Street, Hohhot, Inner Mongolia, 010059, China.
Rongrong ZhangClinical Research Center, Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Hohhot, Inner Mongolia, 010030, China.ORCID http://orcid.org/0009-0005-8646-4088
Mengxuan JiaClinical Research Center, Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Hohhot, Inner Mongolia, 010030, China.ORCID http://orcid.org/0009-0009-8805-5957
Shuting LanClinical Research Center, Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Hohhot, Inner Mongolia, 010030, China.ORCID http://orcid.org/0009-0007-0870-6306
Xiaomei SunClinical Research Center, Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Hohhot, Inner Mongolia, 010030, China.ORCID http://orcid.org/0009-0004-1829-0867
Zhikang WangCollege of Life Science, Inner Mongolia University, 235 West University Road, Hohhot, Inner Mongolia, 010021, China.
Yanfeng DaiCollege of Life Science, Inner Mongolia University, 235 West University Road, Hohhot, Inner Mongolia, 010021, China.
Shuwei YangDepartment of Public Health, Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Hohhot, Inner Mongolia, 010030, China. 1196777138@qq.com.

Funding

Outstanding Young Talents Cultivation Program of Grassland Elite in Inner Mongolia Q202286the Joint Fund Research Project of Inner Mongolia Medical University YKD2022LH002the Natural Science Foundation of Inner Mongolia 2024LHMS08006the Zhiyuan Talents Cultivation Program of Mongolia Medical University ZY20242129
6 · The paper itself

Abstract

The therapeutic role and mechanisms of selenium nanoparticles (SeNPs) in cyclophosphamide (CTX)-induced premature ovarian failure (POF) remain unclear. In the present study, female mice were treated with CTX to induce POF, followed by SeNPs administration for 14 consecutive days. Ovarian weight, index, and serum hormone levels were measured to assess ovarian function. Histological examination of ovarian tissues was conducted to examine morphological changes, folliculogenesis, DNA damage, and apoptosis. Transcriptomic analysis was performed to identify the underlying molecular mechanisms, with in vitro studies on ovarian granulosa cells employed to validate the findings. The results confirmed that SeNPs administration effectively restored ovarian morphology and function, increasing the number of developing follicles and decreasing the number of atretic follicles. Notably, SeNPs significantly reversed CTX-induced hormonal disturbances: estradiol (E

Indexed as

CyclophosphamideFerroptosisNanoparticlesPhosphatidylinositol 3-KinasesPrimary Ovarian InsufficiencyProto-Oncogene Proteins c-aktSeleniumAnimalsApoptosisDisease Models, AnimalFemaleGranulosa CellsMiceOvarySignal TransductionCyclophosphamidePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSeleniumAnd ferroptosisCyclophosphamidePI3K/AKT signaling pathwayPremature ovarian failureSelenium nanoparticles

Identifiers

PMID41239508
PMCPMC12619377

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.