Evidence map›Paper›PMID 41239530›Full record

ArticleAntimicrobial resistance and infection control2025

Sustained effect of a multifaceted VAP prevention program over more than seven years including the COVID-19 pandemic.

Andrea C Büchler, Holly Jackson, Niccolò Buetti, Filippo Boroli, Christophe Juge, Aurélie Perret, Zilfi Koyluk Tomsuk, Caroline Landelle, Stephan Harbarth, Jérôme Pugin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial resistance and infection control, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrea C BüchlerInfection Control Program and WHO Collaborating Center, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Holly JacksonInfection Control Program and WHO Collaborating Center, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Niccolò BuettiInfection Control Program and WHO Collaborating Center, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Filippo BoroliDivision of Intensive Care, University Hospitals of Geneva and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Christophe JugeDivision of Intensive Care, University Hospitals of Geneva and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Aurélie PerretDivision of Intensive Care, University Hospitals of Geneva and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Zilfi Koyluk TomsukDivision of Intensive Care, University Hospitals of Geneva and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Caroline LandelleInfection Control Unit, Grenoble Alpes University Hospital, Grenoble, France.
Stephan HarbarthInfection Control Program and WHO Collaborating Center, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Jérôme PuginDivision of Intensive Care, University Hospitals of Geneva and Faculty of Medicine, University of Geneva, Geneva, Switzerland. jerome.pugin@unige.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the long-term impact of a multifaceted intervention bundle containing nine measures to reduce the incidence of ventilator-associated pneumonia (VAP) in mechanically ventilated patients admitted to the intensive care division at Geneva University Hospitals over a prolonged follow-up period of more than seven years, including the COVID-19 pandemic. The original study included a follow-up of 11 months and showed a marked decrease in VAP incidence. We compared the five pre-defined time periods (pre-intervention, intervention, post-intervention, prolonged follow-up, and COVID-19 pandemic period) using a Poisson model. The incidence of VAP per 1000 ventilator days reduced from 24.3 (95% confidence interval [CI] 18.8-30.9) in the pre-intervention period to 3.9 (95%CI 2.0-6.8) in the post-intervention period. During the prolonged follow-up and the COVID-19 pandemic periods, VAP incidence per 1000 ventilator-days remained similar as in the initial post-intervention period with 4.0 (95%CI 2.9-5.4) and 3.7 (95%CI 2.8-4.7), respectively. Adherence to the bundle measures was assessed using the monthly percentage of correct observations and shown overall for each of the five time periods. Adherence to all but two bundle measures (oral care and hand hygiene) remained high or even improved during the prolonged follow-up period. In conclusion, after implementing a VAP prevention bundle in 2014, there was a sustained effect on VAP incidence during a 7-year follow-up, including the COVID-19 pandemic period.

Indexed as

COVID-19Infection ControlPneumonia, Ventilator-AssociatedAgedFemaleHumansIncidenceIntensive Care UnitsMaleMiddle AgedPandemicsRespiration, ArtificialSARS-CoV-2SwitzerlandBundlesImplementationIntensive care unitMultimodal strategyPrevention and controlVentilator-associated pneumonia

Identifiers

PMID41239530
PMCPMC12619505

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.