Evidence map›Paper›PMID 41240153›Full record

ArticleBiogerontology2025

Causal effects of immune cell populations on biological aging: a Mendelian randomization study.

Jingfeng Fu, Wei Wu, Shangren Shen

Abstract read
PubMed Publisher
In one paragraph

Article in Biogerontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jingfeng FuSchool of Pharmacy and Medical Technology, Putian University, Putian, 351100, China. fujingfeng361@163.com.
Wei WuSchool of Pharmacy and Medical Technology, Putian University, Putian, 351100, China.
Shangren ShenSchool of Pharmacy and Medical Technology, Putian University, Putian, 351100, China.

Funding

the Startup Fund for Advanced Talents of Putian University 2024131
6 · The paper itself

Abstract

While immune system involvement in aging is increasingly recognized, causal relationships between specific immune cell populations and biological aging indicators remain unclear. We aimed to identify immune targets influencing aging trajectories to inform future immunomodulatory interventions. We conducted two-sample Mendelian randomization (MR) analysis using immunophenotype GWAS data (3,757 Sardinian participants) and aging phenotype statistics (PhenoAgeAccel: n = 107,460; BioAgeAccel: n = 98,446). Analysis employed IVW methodology with sensitivity analyses including weighted median estimation, MR-Egger regression, MR-PRESSO, and Cochran's Q statistic. Significance was determined using False Discovery Rate (FDR) correction (P

Indexed as

AgingAgedFemaleGenome-Wide Association StudyHumansMaleMendelian Randomization AnalysisMiddle AgedPhenotypeBiological agingGenome-wide association studyImmune cellsMendelian randomization

Identifiers

PMID41240153

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.