ReviewMolecular diversity2026
Loliolide: green monoterpenoid lactone with therapeutic and ecological significance-a comprehensive review with computational validation.
Review in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Total synthesis of pyridine-containing natural product Lycodine as well as its dimers and derivatives.Molecular diversity · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural monoterpenoid lactone, loliolide has garnered scientific attention due to its multifunctional pharmacological, ecological, and biochemical activities. Ubiquitously found in marine algae, terrestrial organisms, fungi, and certain animal organisms, loliolide possesses a wide range of biological activities, including anti-inflammatory, antioxidant, anticancer, neuroprotective, antidiabetic, antidepressant, immunosuppressive, antiviral, and allelopathic activities. This review provides a comprehensive overview of the pharmacological activities with molecular mechanism, and ecological roles of loliolide with a specific focus on its drug-likeness profile (in silico) and therapeutic potential. Mechanistically, loliolide acts through modulation of critical pathways such as NRF2/ARE, NF-κB, MAPK, AMPK, and Wnt/β-catenin. Additionally, the compound's allelopathic activity makes it a viable green substitute in agrochemicals. Furthermore, In silico assessments (ADME, molecular networking/docking) reinforce its drug-like properties, with favorable ADMET characteristics. GO and Kegg pathway analysis demonstrated that loliolide works by interfering by inflammation and and other mechanistic pathways. Molecular docking showed strong binding affinities - 10.2 and - 8.7, - 7.4 and - 7.3 with receptor COX2[ICX2], apoptosis[5O10], anti-aging[7ZBF] and anti-oxidant [ 2HE3] respectively. Overall, this review provides the multifunctional potential of loliolide as a prospective bioactive molecule in drug discovery and environmental biotechnology.
Indexed as
Identifiers
41240212What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.