ArticleJournal of assisted reproduction and genetics2026
Overexpression of renin-angiotensin system peptides and receptors (OVRAS) in androgen-induced PCOS mouse ovaries.
Article in Journal of assisted reproduction and genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe ovarian renin-angiotensin system (OVRAS) plays a key role in ovarian physiology and pathology, regulating angiogenesis, steroidogenesis, follicular development, and ovulation. This study examines OVRAS expression in normal and dihydrotestosterone (DHT)-induced polycystic ovary syndrome (PCOS) mouse model to elucidate its role in PCOS pathogenesis.
methodsOvarian tissues from normal and DHT-treated mice were analyzed by double and triple immunofluorescence to localize angiotensin peptides (Ang II/III, Ang 1-7) and their receptors (AT1R, AT2R, MasR) within granulosa (GCs), theca (TCs), follicular contents, and interstitial cells (ICs) at preantral and antral stages.
resultsNormal ovaries exhibited stage-specific OVRAS expression, with Ang 1-7 progressively localizing toward the oocyte in antral follicles and Ang II-III showing strong expression in cells adjacent to the antrum. In DHT-treated ovaries, OVRAS was dysregulated, showing irregular Ang 1-7 staining in GCs, decreased AT1R, increased AT2R, and loss of Mas1R expression. DHT-PCOS follicles displayed impaired development, thickened theca layers, and OVRAS overexpression in ICs. The zona pellucida (ZP) was strongly stained in normal follicles but weakened in the distorted ZPs of DHT-treated mice.
conclusionsOVRAS shows hormone-regulated expression during normal folliculogenesis and is disrupted in the DHT-induced PCOS mouse model, paralleling human pathology. Its upregulation in interstitial cells following androgen exposure is associated with theca cell hyperplasia and excess androgen production, suggesting a role in PCOS-related follicular dysfunction. These results position OVRAS as a potential molecular marker and therapeutic target in ovarian disorders. Further studies are needed to clarify its function in follicular maturation and oocyte quality. .
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.