Evidence map›Paper›PMID 41240300›Full record

ArticleBiological trace element research2026

Association of Urine Heavy Metals with Prevalence of Type 1 Diabetes and Poor Glycaemic Control.

Samrat Ashok Vasudevan, Srinidhi Narayani Seenivasan, Avinash Kumar Raghupathy, Dinakaran Vasudevan, Parthasarathy Ayothi, Tanmayaa Nayak, Buvaneswari Gajendran, Karthika Durairaj, Divya Shree Sathish, Srilaxmi Balaji and 7 more

Abstract read
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Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Samrat Ashok VasudevanChemomicrobiomics Laboratory, Department of Biochemistry and Microbiology, KMCH Research Foundation, Coimbatore, 641 014, Tamil Nadu, India.
Srinidhi Narayani SeenivasanChemomicrobiomics Laboratory, Department of Biochemistry and Microbiology, KMCH Research Foundation, Coimbatore, 641 014, Tamil Nadu, India.
Avinash Kumar RaghupathyCardio-Hepato-Renal and Metabolic Research Unit, Department of Biochemistry and Microbiology, KMCH Research Foundation, Coimbatore, 641 014, Tamil Nadu, India.
Dinakaran VasudevanChemomicrobiomics Laboratory, Department of Biochemistry and Microbiology, KMCH Research Foundation, Coimbatore, 641 014, Tamil Nadu, India.
Parthasarathy AyothiChemomicrobiomics Laboratory, Department of Biochemistry and Microbiology, KMCH Research Foundation, Coimbatore, 641 014, Tamil Nadu, India.
Tanmayaa NayakDST Unit of Nanoscience and TUE, Department of Chemistry, Indian Institute of Technology Madras, Chennai, 600 036, Tamil Nadu, India.
Buvaneswari GajendranChemomicrobiomics Laboratory, Department of Biochemistry and Microbiology, KMCH Research Foundation, Coimbatore, 641 014, Tamil Nadu, India.
Karthika DurairajChemomicrobiomics Laboratory, Department of Biochemistry and Microbiology, KMCH Research Foundation, Coimbatore, 641 014, Tamil Nadu, India.
Divya Shree SathishChemomicrobiomics Laboratory, Department of Biochemistry and Microbiology, KMCH Research Foundation, Coimbatore, 641 014, Tamil Nadu, India.
Srilaxmi BalajiCardio-Hepato-Renal and Metabolic Research Unit, Department of Biochemistry and Microbiology, KMCH Research Foundation, Coimbatore, 641 014, Tamil Nadu, India.
Abisheak KandasamyCardio-Hepato-Renal and Metabolic Research Unit, Department of Biochemistry and Microbiology, KMCH Research Foundation, Coimbatore, 641 014, Tamil Nadu, India.
P AmaravathyChemomicrobiomics Laboratory, Department of Biochemistry and Microbiology, KMCH Research Foundation, Coimbatore, 641 014, Tamil Nadu, India.
Sundaresan MohanrajCardio-Hepato-Renal and Metabolic Research Unit, Department of Biochemistry and Microbiology, KMCH Research Foundation, Coimbatore, 641 014, Tamil Nadu, India.
Shankar DhandapaniDepartment of Endocrinology, Kovai Medical Centre and Hospital, Coimbatore, 641 014, Tamil Nadu, India.
Thalappil PradeepDST Unit of Nanoscience and TUE, Department of Chemistry, Indian Institute of Technology Madras, Chennai, 600 036, Tamil Nadu, India.
Krishnan SwaminathanDepartment of Endocrinology, Madhuram Diabetes and Thyroid Centre, Coimbatore, 641 048, Tamil Nadu, India.
Ganesan VelmuruganChemomicrobiomics Laboratory, Department of Biochemistry and Microbiology, KMCH Research Foundation, Coimbatore, 641 014, Tamil Nadu, India. vel@kmchrf.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging evidence suggests that endocrine-disrupting chemicals specifically heavy metals, may influence metabolic disorders including Type 1 Diabetes mellitus (T1DM). Poor glycaemic control is a key issue in management of T1DM. This cross-sectional study explores the association of toxic heavy metals with prevalence of T1DM and glycaemia. A total of 153 individuals with T1DM with mean age of 13 years and age- and sex matched 60 healthy controls from Coimbatore, South India were recruited. Clinical data including glycated haemoglobin and sociodemographic and environmental exposure data were collected. Urine samples were analysed for Copper (Cu), Zinc (Zn), Cadmium (Cd), Arsenic (As), Barium (Ba) and Lead (Pb), which are all known endocrine-disrupting chemicals. Urinary concentrations of all heavy metals were normalized to urine creatinine and expressed as ug/mg creatinine. The levels of all analyzed metals were significantly higher in T1DM compared to controls. Correlation analysis revealed the positive association between glycaemia and heavy metals. Arsenic and lead showed significant trend with T1D prevalence on comparison to control while zinc and cadmium showed significant trend with uncontrolled glycaemia. This study reveals the association of heavy metals exposure on the etiology and pathophysiology of T1DM. In addition, this study highlights the need of screening of urinary heavy metals as part of metabolic risk assessment and development of targeted therapies for heavy metal detoxification for achieving better glycaemia in T1DM.

Indexed as

Diabetes Mellitus, Type 1Glycemic ControlMetals, HeavyAdolescentAdultCase-Control StudiesChildCross-Sectional StudiesFemaleHumansIndiaMalePrevalenceYoung AdultMetals, HeavyEndocrine-disrupting chemicalsGlycated hemoglobulinHeavy metalsPoor glycaemiaType 1 diabetes mellitusUncontrolled diabetes

Identifiers

PMID41240300

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.