Evidence map›Paper›PMID 41240301›Full record

ArticleBiological trace element research2026

Serum Levels of Trace Elements and Minerals in Non-alcoholic Fatty Liver Disease Patients with and without Type 2 Diabetes are Associated with Metabolic Risk Markers.

Alexey A Tinkov, Tatiana V Korobeinikova, Ji-Chang Zhou, Zhan Shi, Svetlana V Notova, Anna E Pobilat, Rongzhu Lu, Lingna Fang, Anatoly A Kirichuk, Anatoly V Skalny

Abstract read
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In one paragraph

Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Mercury-induced excitotoxicity in autism spectrum disorder: disruption of glutamatergic homeostasis and the therapeutic role of the selenium-glutathione axis.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alexey A TinkovLaboratory of Molecular Ecobiomonitoring and Quality Control, Yaroslavl State University, Yaroslavl, 150003, Russia. tinkov.a.a@gmail.com.
Tatiana V KorobeinikovaCenter of Bioelementology and Human Ecology, IM Sechenov First Moscow State Medical University (Sechenov University), Moscow, 119146, Russia.
Ji-Chang ZhouSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-Sen University, Shenzhen, 518107, China.
Zhan ShiSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-Sen University, Shenzhen, 518107, China.
Svetlana V NotovaInstitute of Bioelementology, Orenburg State University, Orenburg, 460018, Russia.
Anna E PobilatDepartment of Medical Elementology, Department of Human Ecology and Bioelementology, Peoples' Friendship University of Russia, (RUDN University), Moscow, 117198, Russia.
Rongzhu LuDepartment of Preventive Medicine and Public Health Laboratory Sciences, School of Medicine, Jiangsu University, Zhenjiang, 212013, Jiangsu, China.
Lingna FangDepartment of Geriatrics, Kunshan Hospital Affiliated of Jiangsu University, Kunshan, 215300, China.
Anatoly A KirichukDepartment of Medical Elementology, Department of Human Ecology and Bioelementology, Peoples' Friendship University of Russia, (RUDN University), Moscow, 117198, Russia.
Anatoly V SkalnyLaboratory of Molecular Ecobiomonitoring and Quality Control, Yaroslavl State University, Yaroslavl, 150003, Russia.

Funding

Ministry of Science and Higher Education of the Russian Federation FENZ-2023-0004Shenzhen Science and Technology Innovation Program GJHZ20240218114600001
6 · The paper itself

Abstract

The objective of the present study was to assess serum levels of essential trace elements and minerals in non-alcoholic fatty liver disease (NAFLD) patients with and without type 2 diabetes mellitus (T2DM), as well as evaluate their association with metabolic risk biomarkers with adjustment for the prevalence of comorbidities. A total of 260 adults including 77 healthy controls, 107 NAFLD patients without T2DM, and 76 subjects having both NAFLD and T2DM were enrolled in the study. Anthropometric parameters and the prevalence of concomitant diseases were registered. Serum trace element and mineral levels were evaluated using inductively coupled plasma mass-spectrometry. In addition, blood glucose, liver damage markers, and other markers of metabolic risk were assessed using spectrophotometry. The obtained data showed that along with markers of liver damage like ALT and GGT activity, NAFLD patients, especially those having T2DM, are also characterized by hyperglycemia and dyslipidemia. NAFLD patients were also characterized by significantly lower serum Ca, Co, Fe, Mg, and especially Zn levels, being the lowest in NAFLD patients with T2DM. In contrast, a decline in serum Mn and Se concentration was observed only in NAFLD patients without T2DM compared to control subjects. Multiple linear regression analysis with adjustment for various comorbidities revealed a tight inverse association between circulating levels of Zn and metabolic risk markers including ALT activity, glucose, and HbA1c levels, while serum Cu and Se were positively associated with certain parameters. These findings suggest that disturbances of trace element and mineral metabolism are significantly associated with more profound metabolic alterations in NAFLD patients with T2DM.

Indexed as

Diabetes Mellitus, Type 2MineralsNon-alcoholic Fatty Liver DiseaseTrace ElementsAdultBiomarkersFemaleHumansMaleMiddle AgedRisk FactorsBiomarkersMineralsTrace ElementsFatty liverMetabolic syndromeSeleniumType 2 diabetes mellitusZinc

Identifiers

PMID41240301

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.