Evidence map›Paper›PMID 41240337›Full record

ArticleCell reports2025

Temporary retinal inactivation reverses effects of long-term monocular deprivation in visual cortex by induction of burst mode firing in the thalamus.

Madison Echavarri-Leet, Tushar Chauhan, Teresa L M Cramer, Ming-Fai Fong, Mark F Bear

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Madison Echavarri-LeetThe Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Tushar ChauhanThe Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Teresa L M CramerThe Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Ming-Fai FongThe Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Mark F BearThe Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: mbear@mit.edu.

Funding

Behavioral Consequences and cellular substrates of plasticity in visual cortexR01EY023037 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BEAR, MARK F · 2013 to 2025
$6.0M
How retinal silencing restores synaptic strength in visual cortex of adult amblyopiaR01EY037733 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BEAR, MARK F · 2025 to 2025
$2.3M
Synaptic and intrinsic mechanisms underlying visual cortical enhancement following retinal inactivationK99EY029326 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FONG, MING-FAI · 2018 to 2020
$261k
Elucidating the Role of Dorsal Lateral Geniculate Nucleus Burst-Mode Firing in Retinal Inactivation Induced Recovery from Monocular DeprivationF31EY033996 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LEET, MADISON · 2022 to 2024
$143k
NEI NIH HHS F31 EY033996NEI NIH HHS K99 EY029326NEI NIH HHS R01 EY023037NEI NIH HHS R01 EY037733
6 · The paper itself

Abstract

Monocular deprivation during an early postnatal critical period causes amblyopia, an impairment of vision in one eye, by altering the development of synapses in the primary visual cortex (V1). Prior studies have shown that these synaptic changes can be rapidly reversed after the critical period by temporarily inactivating the non-deprived (fellow) eye with tetrodotoxin (TTX). Here, we show in mice that the inactivation of one eye causes dorsal lateral geniculate nucleus (dLGN) neurons postsynaptic to the other eye to fire in high-frequency bursts due to recruitment of the low-threshold voltage-gated calcium channels. Elimination of bursting by genetic deletion of Ca

Indexed as

RetinaSensory DeprivationThalamusVisual CortexAction PotentialsAmblyopiaAnimalsCalcium Channels, T-TypeGeniculate BodiesMiceMice, Inbred C57BLNeuronsCalcium Channels, T-Typeamblyopiaburst firingCP: neurosciencelateral geniculate nucleusocular dominance plasticitysynaptic plasticityvisual cortex

Identifiers

PMID41240337
PMCPMC12723367

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.