Evidence map›Paper›PMID 41240347›Full record

ArticleChemistry & biodiversity2026

An Exploration of the Antidiabetic Potential of 2-Thio-4-quinazolinone Scaffolds Using In Vitro and In Silico Approaches.

Aamer Saeed, Mian Bilal Haider, Ghulam Shabir, Syeda Abida Ejaz, Hafiz Muhammad Attaullah, Noorul Ain, Muhammad Zaffar Hashmi, Hesham R El-Seedi

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Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aamer SaeedDepartment of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan.ORCID https://orcid.org/0000-0002-7112-9296
Mian Bilal HaiderDepartment of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan.ORCID https://orcid.org/0009-0003-0631-7500
Ghulam ShabirDepartment of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan.
Syeda Abida EjazDepartment of Pharmaceutical Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
Hafiz Muhammad AttaullahDepartment of Pharmaceutical Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
Noorul AinDepartment of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan.
Muhammad Zaffar HashmiDepartment of Environmental Health and Management, Health Services Academy Islamabad, Pakistan.
Hesham R El-SeediDepartment of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes, a complicated metabolic disease, upsets glucose regulation and disturbs multiple organs, often resulting in problems like neuropathy and cardiovascular diseases. There is a pressing need to develop effective antidiabetic agents capable of managing glucose metabolism without compromising vital physiological functions. This study highlights the synthesis of 2-thio-4-quinazolinones (5a-j), the base-catalyzed intramolecular cyclization of corresponding 2-fluorobenzoyl-3-aryl thioureas (4a-j), and their exploration for α- and β-glucosidase inhibition. All the synthesized compounds exhibited strong α- and β-glucosidase inhibition, with compound 5a, containing chloro and nitro substituents, showing the most potent α-glucosidase inhibition with an IC

Indexed as

Glycoside Hydrolase InhibitorsHypoglycemic AgentsQuinazolinonesalpha-GlucosidasesDose-Response Relationship, DrugHumansMolecular Docking SimulationMolecular StructureStructure-Activity Relationshipalpha-GlucosidasesGlycoside Hydrolase InhibitorsHypoglycemic AgentsQuinazolinonesAcyl thioureaComputational studyDiabetesEnzyme inhibitionGlucosidaseQuinazolinone

Identifiers

PMID41240347
PMCPMC13421942

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.