ArticleVox sanguinis2026
Assessment of Leishmania exposure in blood donors from a non-endemic urban area: A study in São Paulo.
Article in Vox sanguinis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Assessment of Leishmania exposure in blood donors from a non-endemic urban area: A study in São Paulo.Vox sanguinis · 2026Article
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Authors and funding
15 authors.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesAccording to the World Health Organization, more than 1 billion people are at risk of leishmaniasis in over 89 countries. Environmental changes such as deforestation, urban expansion and climate change facilitate the spread of sand fly vectors and reservoirs, increasing disease transmission. The introduction of Leishmania into non-endemic regions may be further driven by globalization and ecotourism. Transfusion transmission, particularly of Leishmania infantum, remains a concern due to the parasite's ability to survive under blood storage conditions and its prolonged latent phase. We aimed to determine the prevalence of Leishmania spp. among blood donors in a non-endemic region. MATERIALS AND
methodsA prospective, cross-sectional study was conducted with 5145 blood donor samples collected from January to December 2023. Serological screening was performed using an in-house immunoglobulin G (IgG) ELISA based on Leishmania chagasi antigen. Samples with positive or inconclusive ELISA results were further tested by real-time PCR targeting internal transcribed spacer (ITS) and kinetoplast DNA (kDNA) regions, according to Pirmez et al.
resultsAmong samples tested, 2.82% (141/5145) were ELISA-reactive. None of these were positive by PCR for ITS or kDNA.
conclusionThe absence of Leishmania DNA in ELISA-reactive samples highlights the limitations of serological screening in low-endemicity areas. Inflammatory physiological conditions, such as pregnancy and abortion, may contribute to non-specific reactivity. The incorporation of molecular methods and the adoption of universal leukoreduction are recommended measures to ensure transfusion safety and avoid unnecessary donor deferrals.
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