ArticlePhysiological reports2025
Proximal pulmonary artery wall shear stress derived from computational fluid dynamics: A noninvasive biomarker for CTEPH and perfusion mismatch.
Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Research advances in chronic thromboembolic pulmonary hypertension: from pathological mechanisms to multidisciplinary management.Frontiers in cardiovascular medicine · 2026Review
- Proximal pulmonary artery wall shear stress derived from computational fluid dynamics: A noninvasive biomarker for CTEPH and perfusion mismatch.Physiological reports · 2025Article
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Authors and funding
16 authors.
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Abstract
Chronic thromboembolic pulmonary hypertension (CTEPH) is a severe complication of pulmonary embolism (PE), often diagnosed late due to nonspecific symptoms and limitations of current screening tools like V/Q scintigraphy. This study investigated whether computational fluid dynamics (CFD)-derived hemodynamic parameters, specifically time-averaged wall shear stress (TAWSS) and oscillatory shear index (OSI), in the proximal pulmonary arteries could serve as noninvasive biomarkers for CTEPH and chronic thromboembolic disease without pulmonary hypertension (CTEPD, non-CTEPH with V/Q mismatches). We retrospectively analyzed 90 patients (30 CTEPH, 30 CTEPD, and 30 controls without mismatch) using patient-specific 3D CFD models reconstructed from CTPA, with RCR boundary conditions tuned to RHC data. We found significantly reduced median TAWSS in CTEPH (16.5 dyn/cm
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