ArticleAesthetic surgery journal2026
A Multicenter, Open-Label Study of Combined Poly-L-Lactic Acid and Hyaluronic Midface Filler Regimen Enhances Facial Harmony and Skin Quality in GLP-1 Medication Users.
Article in Aesthetic surgery journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Beyond Weight Loss: Facial Remodeling Associated with GLP-1 Receptor Agonists-A Systematic Review and Therapeutic Framework.Aesthetic plastic surgery · 2026Review
- The Expanding Role of GLP-1 Receptor Agonists and Dual GIP/GLP-1 Agonists in Dermatology: From Immunometabolism to Clinical Practice.Dermatology and therapy · 2026Review
- Regenerative Functional Microspheres for Aesthetic Medicine: Mechanism, Materials, Fabrication, and Clinical Applications.Advanced healthcare materials · 2026Review
- A Case Series on a Layered Biomaterial Strategy for Midface Rejuvenation: Combining Collagen Stimulators and Hyaluronic Acid.Journal of cosmetic dermatology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundWeight loss induced by glucagon-like peptide-1 receptor agonists (GLP-1 RAs) can lead to facial volume loss, wrinkles, and sagging skin, resulting in an aged and gaunt appearance that negatively affects subject satisfaction and self-perception.
objectivesThis study assessed the treatment regimen of poly-L-lactic acid (PLLA-SCA) and 2 hyaluronic acid midface fillers (HA-LYF, HA-CON) on restoring facial balance, correcting contour deficiencies, and improving skin quality in subjects who experienced weight loss from GLP-1 RA therapy.
methodsThis multicenter, open-label study enrolled 41 subjects with cheek wrinkles and midface contour deficiencies following GLP-1 RA-driven weight loss. Subjects received 2 to 3 treatment sessions of PLLA-SCA and 1 to 2 treatment sessions of HA-LYF or HA-CON, with follow-ups through 9 months since the last PLLA-SCA treatment. Efficacy evaluations included objective skin quality assessments using bioinstrumentation, improvements in facial contour deficiencies using standardized photography, and subject self-assessment questionnaires. Safety was also monitored throughout the study.
resultsThe PLLA-SCA and HA-LYF or HA-CON treatment regimen significantly improved facial skin quality and enhanced contour in the cheek, jawline, and perioral areas, and demonstrated objective improvement in hydration and skin radiance. Additionally, subjects were satisfied with the treatment results, with no treatment-related adverse events reported.
conclusionsPLLA-SCA and HA-LYF or HA-CON provided effective, safe, and sustained improvements in facial balance, contour, and skin quality in subjects who experienced facial volume loss and ageing from weight loss following GLP-1 RA therapy. LEVEL OF EVIDENCE: 3 (THERAPEUTIC):
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.