ArticleThe Journal of clinical endocrinology and metabolism2026
Brown Adipose Tissue and Metabolic Markers Differ Between Greenlanders and Danes With Cold Activation.
Article in The Journal of clinical endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Brown Adipose Tissue and Metabolic Markers Differ Between Greenlanders and Danes With Cold Activation.The Journal of clinical endocrinology and metabolism · 2026Article
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11 authors.
Funding
Abstract
contextBrown adipose tissue (BAT) is a thermogenic tissue that converts energy into heat in response to cold exposure, and is therefore a promising target for improving cardiometabolic health. Habitually cold-exposed Arctic people represent a unique model of metabolic adaptation to cold.
objectiveWe investigated cold-induced BAT activation in Greenlanders in comparison to Danes.
methodsA comparative crossover study was conducted of 13 Greenlanders and 11 Danes, with 2 experimental sessions conducted 2 weeks apart: A, a thermoneutral session; and B, a cooling session. BAT volume and activity were assessed using 2-deoxy-2-[18F]-fluoro-D-glucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) imaging. Serial measurement of metabolic markers associated with BAT activity was performed by blood sampling.
resultsBoth for Greenlanders and Danes, core temperature decreased 0.5 °C during cooling, and the volume of active BAT increased, yet with a higher increase in active BAT volume of 16 917% in Greenlanders compared to 4541% in Danes (P = .046). Marked differences in glucose levels were seen in Greenlanders and Danes in response to cooling (Danes: 0.30 mmol/L, P = .013; Greenlanders: 0.16 mmol/L, P = .12), insulin (Danes: 2.43 pmol/L, P = .32; Greenlanders: 6.65 pmol/L, P = .001), triglycerides (Danes: -0.59 mmol/L, P < .001; Greenlanders: -0.16 pmol/L, P = .21), and total cholesterol (Danes: 0.39 mmol/L, P < .001; Greenlanders: 0.02 mmol/L, P = .89).
conclusionThe larger increase in BAT activity in response to cooling and the dampened response in metabolic parameters in Greenlanders compared to Danes leads to a hypothesis of preparedness for rapid thermogenic response to cold exposure in populations with active BAT.
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