SynthesisAnaesthesia2026
Interventions to prevent postoperative neurocognitive complications: an umbrella review of meta-analyses of randomised controlled trials.
Synthesis in Anaesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Mapping the Neuroprotective Landscape of Perioperative Magnesium Sulphate: A Translational Scoping Review.Journal of clinical medicine · 2026Review
- Effect of Remimazolam on Postoperative Delirium in Elderly Surgical Patients: A Critical Review of Pharmacological Mechanisms and Clinical Evidence.Drug design, development and therapy · 2026Review
- Effect of electroacupuncture on postoperative delirium in elderly patients undergoing laparoscopic radical prostatectomy: study protocol for a double-center randomized controlled trial.Frontiers in medicine · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe certainty of the effectiveness of interventions to manage postoperative neurocognitive complications remains unclear. The objective of this umbrella review was to synthesise and evaluate the evidence for interventions aimed at reducing the incidence of peri-operative neurocognitive complications.
methodsWe searched relevant databases from inception to 23 August 2025. We included systematic reviews and meta-analyses of randomised trials evaluating pharmacological and non-pharmacological interventions for the prevention of postoperative neurocognitive complications in adult surgical populations. Certainty of evidence for each intervention was assessed using the GRADE framework. Methodological quality was appraised using AMSTAR and the Ioannidis classification.
resultsA total of 114 systematic reviews and meta-analyses, with data from 250,777 patients, were included. Dexmedetomidine, cerebral monitoring, acupuncture, sleep interventions, steroids, antipsychotics, peripheral nerve blocks, esketamine and remimazolam were associated with reductions in postoperative neurocognitive complications. Subgroup analyses indicated that these interventions also showed potential benefits across non-cardiac, orthopaedic and cardiac surgery. However, the overall certainty of evidence for all these interventions was predominantly very low. DISCUSSION: A number of peri-operative interventions are associated with a reduction in postoperative neurocognitive complications but the certainty of evidence supporting these interventions to prevent is very low. High-quality research is needed to advance the evidence base and inform future clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.