ArticleAnnals of medicine2025
Association between triglyceride-glucose index upon admission and the subsequent occurrence of acute kidney injury in adult patients with diabetic ketoacidosis: a single-center retrospective cohort study.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- Triglyceride-Glucose Index and Acute Kidney Injury: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Comments on "association between triglyceride-glucose index upon admission and the subsequent occurrence of acute kidney injury in adult patients with diabetic ketoacidosis: a single-center retrospective cohort study".Annals of medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explore the association between the triglyceride-glucose (TyG) index at admission and subsequent acute kidney injury (AKI) in adult patients with diabetic ketoacidosis (DKA), and to examine whether a data-driven threshold could aid early risk stratification.
methodsWe conducted a single-centre retrospective cohort study of adults admitted with DKA. Clinical and laboratory variables were extracted and curated from electronic medical records. The TyG index was derived from routine triglyceride and glucose measurements obtained at admission. AKI during hospitalization was defined by KDIGO creatinine criteria. We modelled TyG using restricted cubic splines and in quartiles; multivariable logistic regression adjusted for prespecified confounders. Subgroup analyses evaluated effect modification by sex, age, BMI, diabetes type, and hypertension.
resultsA total of 678 adults with DKA were included; 196 (28.9%) developed AKI. The TyG-AKI relationship was non-linear, with risk rising steeply once TyG exceeded 10.92 (Q4). In fully adjusted models, Q4 vs Q1 was associated with higher odds of AKI (OR 2.478, 95% CI 1.285-4.780;
conclusionsWe observed a non-linear association between admission TyG and subsequent AKI in adults with DKA, with an inflection around TyG ≈ 10.92. These results may help identify patients who warrant closer renal surveillance, yet they should be regarded as exploratory and hypothesis-generating given the single-centre, retrospective design; causality cannot be inferred, and prospective multicentre validation is required before routine clinical adoption.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.