ArticleFrontiers in endocrinology2025
Periodontal therapy mitigates inflammation via TNF-α reduction and improves glycolipid metabolism in diabetic patients: a cross-sectional cohort study.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Review
- The oral‒gut axis in periodontal disease: a systematic review of the associated human evidence of its mechanisms and implications for patient care.Journal of oral microbiology · 2026Review
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Authors and funding
8 authors.
Funding
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Abstract
Objective: To evaluate the effects of non-surgical periodontal therapy on systemic and local levels of tumor necrosis factor-alpha (TNF-α) and their relationship with glycolipid metabolism in patients with type 2 diabetes mellitus (T2DM) and periodontitis. Methods: In this prospective cohort study, 234 patients with T2DM and periodontitis underwent standardized non-surgical periodontal therapy, including scaling and root planing, supplemented with systemic antibiotics. Clinical parameters (gingival bleeding index, periodontitis staging and grading), serum levels of TNF-α, HbA1c, leptin, adiponectin, resistin, free fatty acids (FFA), and levels of TNF-α, leptin, adiponectin, and resistin in gingival crevicular fluid (GCF) were assessed at baseline, 4 weeks, and 8 weeks post-treatment. Correlations were analyzed using Spearman's rank correlation with false discovery rate correction. Results: Periodontal therapy resulted in significant improvements in all clinical periodontal parameters (P<0.01). Systemic and local GCF levels of TNF-α, leptin, resistin, and FFA demonstrated significant and progressive reductions, while adiponectin levels increased significantly at 4 and 8 weeks (P<0.01). HbA1c and FBG levels were also significantly improved by week 8 (P<0.01). TNF-α dynamics were strongly correlated with adipokine levels and clinical indices, with the most robust correlations observed within the GCF microenvironment. Conclusion: Systematic periodontal therapy effectively reduces local and systemic inflammation, improves glycemic control, and ameliorates glycolipid metabolic disorders in patients with T2DM and periodontitis. The strong interrelationships observed, particularly within the GCF, underscore the potential role of TNF-α as a key mediator in the mouth-systemic metabolic interplay.
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