ArticleAmerican journal of cancer research2025
Early detection of chemotherapy-induced cardiotoxicity in lymphoma patients: RT-3DE/2D-STI and predictive role of LAEFa/LASr.
Article in American journal of cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo evaluate the utility of real-time three-dimensional echocardiography (RT-3DE) and two-dimensional speckle tracking imaging (2D-STI) for early detection of chemotherapy-induced cardiotoxicity in lymphoma patients, and to identify independent predictors of cardiotoxicity using these imaging parameters.
methodsWe conducted a single-center retrospective cohort study at The First People's Hospital of Changde City, enrolling 110 lymphoma patients who received anthracycline-based chemotherapy between January 2020 and January 2024. Echocardiographic assessments, including RT-3DE and 2D-STI, were performed before chemotherapy and within 72 hours after the 3rd and 6th cycles. Cardiotoxicity was defined as a ≥ 10% reduction in left ventricular ejection fraction (LVEF) or an LVEF < 50%.
resultsBaseline clinical characteristics showed significant differences in gender and hypertension between the cardiotoxic and non-cardiotoxic groups (both P < 0.05). RT-3DE revealed time-dependent changes, with LAEFa higher and LAEFa/LAEFt lower in the cardiotoxic group at 3 and 6 weeks post-chemotherapy, respectively (all P < 0.05). 2D-STI showed significant differences in LASct and LASr at 3 and 6 weeks (all P > 0.05). GEE analysis indicated that changes in LAEFa, LAEFp, LAEFt, LASr, LASct, and LVEF were driven by the time × group interaction effect (all P < 0.05).
conclusionRT-3DE and 2D-STI are sensitive for early detection of anthracycline-induced cardiotoxicity in lymphoma patients. LA functional indices (LAEFa, LAEFp, LAEFt) and LA strain indices (LASr, LASct) may detect cardiotoxicity earlier than LVEF, suggesting their potential role in optimizing cardio-oncology monitoring strategies.
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