ArticleASM case reports2025
Report of two severe cases of Japanese encephalitis virus in travelers returning to France, 2023-2024: clinical, diagnostic, and public health implications.
Article in ASM case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
Background: Japanese encephalitis virus (JEV) is a mosquito-borne pathogen responsible for Japanese encephalitis (JE) clinical cases in Asia and the Western Pacific. Non-JE-vaccinated patients can develop potentially life-threatening neurologic forms. Case Summary: Here, we present two severe, non-fatal JEV cases in returning travelers from Cambodia (Case 1) and Cambodia and Vietnam (Case 2), imported to France in 2023-2024. Neither patient was vaccinated, and both presented neurologic symptoms requiring hospitalization. Cases were confirmed by RT-qPCR, IgM, and IgG rise and seroneutralization. Interestingly, this is the second report to describe the detection of the JEV genome in urine by RT-qPCR. Conclusion: This study highlights the critical importance of JE vaccination and the implementation of other personal protective measures to avoid mosquito bites when traveling to a JEV-endemic region.
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