ReviewPakistan journal of medical sciences2025
Can the triglyceride-glucose index predict stroke outcomes? A systematic review and meta-analysis.
Review in Pakistan journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Progress in research on the association between glucose metabolism disorders and intracranial and extracranial atherosclerotic stenosis.Frontiers in cardiovascular medicine · 2026Review
- Association of the single point insulin sensitivity estimator index with functional outcomes and hemorrhagic transformation in patients with acute ischemic stroke.Frontiers in nutrition · 2026Article
- Tirofiban combined with aspirin for branch atheromatous disease: a propensity score-matched study.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To assess the link between the triglyceride-glucose (TyG) index and stroke-related outcomes. Methodology: PubMed, Embase and Scopus databases were searched between January 1, 2000 to November 15, 2024 for studies reporting association between TyG and stroke outcomes. Pooled effect sizes were calculated as relative risks (RR) with 95% confidence intervals (CI). Results: Twenty five studies were included. High TyG levels significantly correlated with increased mortality during hospital stay (RR 1.70, 95% CI: 1.15 to 2.52), at three months (RR 1.96, 95% CI: 1.12 to 3.45) and at 12 months (RR 1.43, 95% CI: 1.07 to 1.91) follow-ups. Similarly, high TyG levels were linked to higher recurrence risk at three months (RR 2.75, 95% CI: 1.31 to 5.78) and 12 months (RR 1.41, 95% CI: 1.18 to 1.68) post-stroke. Elevated TyG was also linked to an increased risk of early neurological deterioration (END) during hospital stay (RR 3.28, 95% CI: 1.71 to 6.30) and poor functional outcome at three months (RR 1.67, 95% CI: 1.18 to 2.37) follow-up. Subgroup analyses showed consistent results across study designs, geographic locations and sample sizes. Low to very low certainty of evidence across various outcomes was detected by GRADE. Conclusions: Elevated TyG index might be a significant predictor of mortality, recurrence, END and poor functional outcomes in stroke patients, emphasizing its potential as a prognostic biomarker. Further studies are needed to explore its utility in clinical decision-making.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.