Evidence mapPaperPMID 41244631Full record

ArticleFrontiers in toxicology2025

Alternatives to animal-derived extracellular matrix hydrogels? An explorative study with HepaRG cells in animal-free hydrogels under static and dynamic culture conditions.

Katharina S Nitsche, Paul L Carmichael, Sophie Malcomber, Iris Müller, Hans Bouwmeester

Abstract read
In one paragraph

Article in Frontiers in toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Katharina S NitscheDivision of Toxicology, Wageningen University, Wageningen, Netherlands.
Paul L CarmichaelDivision of Toxicology, Wageningen University, Wageningen, Netherlands.
Sophie MalcomberUnilever Safety, Environmental and Regulatory Science (SERS), Colworth Science Park, Sharnbrook, United Kingdom.
Iris MüllerUnilever Safety, Environmental and Regulatory Science (SERS), Colworth Science Park, Sharnbrook, United Kingdom.
Hans BouwmeesterDivision of Toxicology, Wageningen University, Wageningen, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New approach methodologies (NAMs) aim for animal-free chemical risk assessments. However, many

Indexed as

3R principlemicrophysiological systemsnew approach methodologiesnext-generation risk assessmentorgan-on-chip

Identifiers

PMID41244631
PMCPMC12611971

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.