SynthesisFrontiers in psychiatry2025
Effect of acupuncture on neuroinflammatory responses in depression animals: a systematic review and meta-analysis.
Synthesis in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Background: Depression causes many negative effects and even death to patients; the burden on society is also heavy in terms of economics. The neuroinflammatory mechanism of acupuncture regulating depression is unclear. Thus, this study evaluated the effect of acupuncture on neuroinflammatory responses in depression animals and provided a clinical reference for depression treatment. Methods: The Web of Science, Embase, the Cochrane Library, PubMed, CNKI, WanFang, CBM, and VIP databases were searched. The SYRCLE Risk of Bias Tool was used to assess bias in the studies. Meta-analysis was performed using Stata 15.0. The sources of heterogeneity were explored using subgroup analysis, and stability was evaluated using sensitivity analysis. Quality of evidence for outcomes was assessed using GDT. Results: This study included 25 studies and 466 animals. According to meta-analysis, compared with the control group, acupuncture significantly reduced IL-1β (SMD: -1.62, 95% CI: -1.93, -1.31), IL-6 (SMD: -1.89, 95% CI: -2.51, -1.26), and TNF-α in depression animals (SMD: -2.09, 95% CI: -2.83, -1.34) and improved IL-4 (SMD: 1.01, 95% CI:0.35, 1.67), IL-10 (SMD:0.77, 95% CI:0.26, 1.28), body weight (SMD:1.69, 95% CI: 1.23, 2.15), crossing numbers (SMD: 1.74, 95% CI: 1.31, 2.17), and rearing numbers (SMD: 1.77, 95% CI: 1.16, 2.39). Conclusion: Acupuncture has the potential to alleviate depression by attenuating neuroinflammatory responses, and the mechanism may be related to modulating the release of inflammatory factors as well as regulating the activation of microglia. Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42024534237.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.