Evidence map›Paper›PMID 41244943›Full record

ArticlePain reports2025

Intact endogenous pain inhibition in complex regional pain syndrome type 1.

Florin Allmendinger, Laura Sirucek, Iara De Schoenmacker, Paulina Simonne Scheuren, Florian Brunner, Petra Schweinhardt, Michèle Hubli

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Article in Pain reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Florin AllmendingerSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0001-7241-565X
Laura SirucekDepartment of Chiropractic Medicine, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Iara De SchoenmackerSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Paulina Simonne ScheurenSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Florian BrunnerPhysical Medicine and Rheumatology, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Petra SchweinhardtDepartment of Chiropractic Medicine, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Michèle HubliSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Impaired endogenous pain modulation is a common characteristic of various chronic pain conditions and may be a key mechanism underlying the development of chronic pain in complex regional pain syndrome (CRPS). One way to assess endogenous pain modulation in humans is through conditioned pain modulation (CPM) paradigms. Objectives: This study aimed to assess CPM capacity in chronic CRPS type 1 and its potential association with the individual pain phenotype. Methods: Sixteen individuals with chronic CRPS type 1 and 15 age- and sex-matched healthy controls (HC) were enrolled. Parallel and sequential CPM paradigms were performed at 2 testing sites: the most painful area and a remote, pain-free area using pressure pain thresholds as a test stimulus and a cold water bath as a conditioning stimulus. Individuals with CRPS underwent pain phenotyping to assess the characteristics of CRPS-related pain. Results: The CPM capacity did not differ between individuals with CRPS and HC ( Conclusion: Our results indicate that in individuals with chronic CRPS type 1, endogenous pain inhibition is intact and comparable with healthy individuals. Therefore, pathomechanisms underlying chronic CRPS are likely related to increased pain facilitatory rather than impaired inhibitory processes.

Indexed as

Chronic painComplex regional pain syndromeConditioned pain modulationDescending pain inhibitionEndogenous pain modulation

Identifiers

PMID41244943
PMCPMC12614675

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.