ArticleInternational journal of general medicine2025
Subclinical Cardiac Dysfunction in Hyperuricemic Gout and Asymptomatic Hyperuricemia: A Comparative Echocardiographic Study.
Article in International journal of general medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study examines subclinical cardiac dysfunction in hyperuricemic populations by comparing echocardiographic parameters-including left ventricular diastolic dysfunction (LVDD), which reflects impaired ventricular relaxation, and left ventricular strain parameters, sensitive markers of early systolic dysfunction-between gout patients and asymptomatic hyperuricemic controls, and identifying echocardiographic and clinical predictors of cardiac impairment. Methods: A cross-sectional study was conducted involving 202 hyperuricemic patients (100 gout and 102 asymptomatic hyperuricemic patients) from a tertiary rheumatology center (June 2021-May 2023). A comprehensive evaluation included conventional echocardiography and two-dimensional speckle-tracking. Biochemical indexes such as serum uric acid (SUA), lipid profiles, and renal function markers, along with demographic data, were collected. Group comparisons, univariate and multivariate regression analyses, and receiver operating characteristic (ROC) analyses assessed associations between echocardiographic parameters and clinical variables. Results: Gout patients had a significantly higher prevalence of LVDD (31.00% vs 10.78%, Conclusion: Distinct echocardiographic profiles and risk factor patterns in gout versus asymptomatic hyperuricemia suggest differing mechanisms of cardiac involvement, underscoring the need for tailored cardiovascular monitoring in hyperuricemic populations.
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