ArticleInternational journal of general medicine2025
Threshold-Triggered Immune Dysregulation Precedes Clinical COPD: A Stage-Specific Diagnostic Model Combining Cytokine Profiling and Lymphocyte Phenotyping.
Article in International journal of general medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Immune-metabolic positive feedback model in COPD: cross-mechanisms and potential intervention strategies.Frontiers in cell and developmental biology · 2026Review
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Authors and funding
5 authors.
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Abstract
Purpose: To establish a stage-specific diagnostic model for chronic obstructive pulmonary disease (COPD) high-risk individuals by characterizing immune dysregulation through integrated cytokine and lymphocyte profiling. Methods: In this cross-sectional study, 116 participants (34 healthy controls, 56 high-risk individuals, and 26 stable COPD patients) underwent comprehensive immunological evaluation. Peripheral blood cytokine levels (IL-6, IL-8, TNF-α) and lymphocyte subsets-including programmed cell death protein 1-positive (PD-1 Results: Threshold-driven immunological alterations were identified in high-risk individuals, marked by a 7.8-fold elevation in PD-1 Conclusion: This study delineates a threshold-triggered immune signature preceding clinical COPD, providing a validated diagnostic framework for early detection. By integrating lymphocyte exhaustion markers and cytokine dynamics, the model bridges a critical gap in identifying subclinical immune dysfunction, enabling targeted interventions prior to irreversible lung damage.
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