Hemoglobin-crosslinked drug-loaded silk fibroin porous scaffold for long-segment tracheal defect repair: An integrated strategy leveraging dynamic mechanical biomimicry and infection control.

Wei Gao, Zhecheng Zha, Leyan Chen, Hongchong Guo, Yang Yang, Qing Xia

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Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Wei GaoDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, China.

Zhecheng ZhaDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, China.

Leyan ChenDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, China.

Hongchong GuoInstitute of Biomaterials and Biomedicine, School of Food and Pharmacy, Shanghai Zhongqiao Vocational and Technical University, Shanghai, 201514, China.

Yang YangDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, China.

Qing XiaDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, China.

Funding

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6 · The paper itself

Abstract

The clinical repair of long-segment tracheal defects (LSTDs) remains a formidable challenge, primarily due to the dynamic mechanical mismatch of current implantable substitutes and high rates of postoperative infection. To address these critical hurdles, we have engineered a novel silk fibroin (SF)-based scaffold, designated Hb-SF@LVX, that simultaneously achieves dynamic mechanical biomimicry and robust infection control. By employing a synergistic dual-crosslinking strategy-combining hemoglobin (Hb)-catalyzed chemical crosslinking with low-temperature-induced β-sheet formation-the scaffold exhibits remarkable elasticity and fatigue resistance, closely mimicking the properties of native tracheal tissue. Furthermore, the scaffold was efficiently loaded with levofloxacin (LVX) and demonstrated prolonged, sustained release, conferring potent antibacterial and

Indexed as

Dual crosslinkingDynamic mechanical biomimicryHierarchical biomimetic structureLevofloxacinSilk fibroin

Identifiers

PMID41245075

DOI10.1016/j.bioactmat.2025.10.024

PMCPMC12617625

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.