ArticleFrontiers in physiology2025
Aerobic training improves exercise capacity after traumatic brain injury in female, but not male, mice.
Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Neurocardiac consequences of traumatic brain injury: integrating neuroimmune, autonomic, and cerebrovascular mechanisms.Frontiers in immunology · 2026Review
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Authors and funding
12 authors.
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Abstract
Introduction: Traumatic brain injury (TBI) often leads to lasting impairments in physical performance, yet its impact on aerobic function and the potential for recovery through exercise remain poorly understood. In this study, we used a well-established controlled cortical impact (CCI) model in mice to address three gaps in the preclinical TBI literature: the effect of injury on voluntary activity and energy metabolism, the extent to which exercise tolerance and cardiorespiratory fitness can be restored through moderate-intensity aerobic training, and whether these responses differ between sexes. Methods: Voluntary wheel running and metabolic outputs following CCI were quantified via the Comprehensive Lab Animal Monitoring System (CLAMS), while maximal oxygen uptake (VO Results: Both sexes displayed similar acute reductions in VO Discussion: These findings reveal a divergence in post-TBI exercise responsiveness and highlight the need for sex-specific, physiology-guided rehabilitation strategies.
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Registered trials
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