ArticleFrontiers in nutrition2025
Effects of barley green on uric acid, inflammatory factors, xanthine oxidase activity and body composition of patients with hyperuricemia: a randomized controlled trial.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06876909 (Clinical Effect Observation of Barley Green Intervention in Hyperuricemia Population and Related Mechanism Study of Xanthine Oxidase), which is not on this map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Clinical Effect Observation of Barley Green Intervention in Hyperuricemia Population and Related Mechanism Study of Xanthine Oxidase
Who cites it
1 citing paper in PubMed.
- Young Barley (Molecules (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: This study aims to evaluate the efficacy of barley green intervention in reducing uric acid (UA) levels, as well as its effects on related inflammatory factors, metabolic indices and body composition in individuals with hyperuricemia. Additionally, we investigate the mechanism of action associated with xanthine oxidase (XOD). Materials and methods: In this randomized controlled trial, patients diagnosed with hyperuricemia were randomly assigned to either an intervention group receiving barley green alongside a balanced diet regimen or a control group adhering solely to a balanced diet. Comprehensive clinical data were collected from participants, and nutritional measurements, UA metabolism-related indicators, inflammatory factor levels, and XOD activity were assessed at various stages over a 3-month period. Results: A total of 90 subjects participated in the study; 49 individuals were included in the intervention group while 25 comprised the control group. The reduction in UA levels-the primary endpoint-was significantly greater after 3 months of intervention compared to those following only a balanced diet [55.00 ± 62.39 vs. 25.00 ± 59.52 ( Conclusion: Oral administration of barley green may contribute to UA regulation and improvements in body composition among individuals with hyperuricemia, with the reduction in XOD activity potentially serving as one of the underlying mechanisms by which barley green exerts its urate-lowering effect. Clinical trial registration: ClinicalTrials.gov, identifier NCT06876909.
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