Evidence map›Paper›PMID 41245492›Full record

ArticleJournal of Alzheimer's disease reports

A preliminary study on the effect of quantified cranial osteopathic manipulation on wild-type and transgenic rat models of Alzheimer's disease.

De'Yana Hines, Hope Tobey, Patrick Dugan, Seth Boehringer, Richard Helm, Ramu Anandakrishnan, Stephen Werre, Pamela VandeVord, Blaise M Costa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

De'Yana HinesDepartment of Biomedical Engineering and Mechanics, Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences, Blacksburg, VA, USA.ORCID https://orcid.org/0009-0009-7956-4717
Hope TobeyEdward Via Virginia College of Osteopathic Medicine, Blacksburg, VA, USA.
Patrick DuganEdward Via Virginia College of Osteopathic Medicine, Blacksburg, VA, USA.
Seth BoehringerDepartment of Biochemistry, Virginia Tech, Blacksburg, VA, USA.
Richard HelmDepartment of Biochemistry, Virginia Tech, Blacksburg, VA, USA.
Ramu AnandakrishnanEdward Via Virginia College of Osteopathic Medicine, Blacksburg, VA, USA.ORCID https://orcid.org/0000-0003-0422-3984
Stephen WerreVirginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA.ORCID https://orcid.org/0000-0003-1638-6705
Pamela VandeVordDepartment of Biomedical Engineering and Mechanics, Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences, Blacksburg, VA, USA.
Blaise M CostaEdward Via Virginia College of Osteopathic Medicine, Blacksburg, VA, USA.ORCID https://orcid.org/0000-0001-6151-2251

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease is a chronic progressive neurodegenerative disorder that impairs the meningeal lymphatics, glymphatic system, and compartmental fluid exchange, leading to a decline in cognitive function. Due to the lack of non-pharmacological and physiological treatments, cranial osteopathic manipulation (COM) poses a potential minimally invasive therapeutic choice. To understand the treatment and related effects objectively, we have established a technique to quantify the force applied during COM on an animal model of AD for the first time. Our results indicate that quantified COM can be applied to rodents to study behavioral and biochemical phenotype changes.

Indexed as

Alzheimer's diseasecranial osteopathic manipulationimmunoassaysosteopathic manipulative medicineosteopathic manipulative treatmentproteomicsspatial learning and memory

Identifiers

PMID41245492
PMCPMC12612521

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.