ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2025
Quantitative CT Assessment of Skeletal Muscle and Abdominal Fat Distribution: Predictive Value for Type 2 Diabetes Mellitus.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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9 authors.
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Abstract
Objective: In this study, we aimed to investigate the association between skeletal muscle area (SMA), subcutaneous fat area (SFA), and visceral fat area (VFA), quantified using computed tomography (CT), and the risk of type 2 diabetes mellitus (T2DM). We also evaluated the predictive performance of these parameters for assessing T2DM risk. Methods: We used a retrospective case-control design, including 207 hospitalized patients who underwent abdominal quantitative CT (QCT) scans at Fushun Central Hospital from July 2021 to July 2022. Using QCT technology, SMA, SFA, and VFA were measured at the level of the third lumbar vertebra. Additionally, the skeletal muscle index (SMI=SMA/height Results: Body mass index, systolic blood pressure, diastolic blood pressure, fasting blood glucose, VFA, and SFA were significantly higher in the T2DM group compared with the control group, and SMA and SMI were significantly lower (all Conclusion: Visceral fat accumulation was an independent risk factor for T2DM, and increased skeletal muscle mass showed a protective effect. The combined SMI and VFA model showed significantly enhanced predictive ability for T2DM risk, suggesting its potential as a clinical biomarker.
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