Evidence map›Paper›PMID 41245762›Full record

ReviewChemical science2025

Construction of artificial organelles

Jiachen Sun, Ruikui Gao, Zhongxuan Yang, Zefeng Deng, Lei Qin, Haiyang Jia, Chun Li

Abstract readReview
In one paragraph

Review in Chemical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Metabolic Engineering for Gibberellic Acid Production inMolecules (Basel, Switzerland) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiachen SunState Key Laboratory of Synthetic Biology, Frontiers Science Center for Synthetic Biology (Ministry of Education), School of Synthetic Biology and Biomanufacturing, School of Chemical Engineering and Technology, Tianjin University Tianjin China lichun@tsinghua.edu.cn.
Ruikui GaoKey Laboratory for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University Beijing China qinleithu@tsinghua.edu.cn.
Zhongxuan YangKey Laboratory for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University Beijing China qinleithu@tsinghua.edu.cn.
Zefeng DengKey Laboratory for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University Beijing China qinleithu@tsinghua.edu.cn.
Lei QinKey Laboratory for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University Beijing China qinleithu@tsinghua.edu.cn.
Haiyang JiaKey Laboratory of Medical Molecule Science and Pharmaceutical Engineering, Ministry of Industry and Information Technology, Institute of Biochemical Engineering, School of Chemistry and Chemical Engineering, Beijing Institute of Technology Beijing China haiyangjia@bit.edu.cn.
Chun LiState Key Laboratory of Synthetic Biology, Frontiers Science Center for Synthetic Biology (Ministry of Education), School of Synthetic Biology and Biomanufacturing, School of Chemical Engineering and Technology, Tianjin University Tianjin China lichun@tsinghua.edu.cn.ORCID https://orcid.org/0000-0003-4262-6848

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein self-assembly represents a highly controllable and versatile strategy for the construction of artificial cells and their functional substructures. By harnessing or engineering the intrinsic assembly properties of natural proteins, diverse and structurally stable artificial organelles can be generated to enable spatial organization of enzymatic catalysis, metabolic pathways, and molecular transport. This review provides a comprehensive overview of representative protein self-assembly systems, including protein cages, scaffolds, and membraneless condensates, with an emphasis on their assembly principles, structural characteristics, and emerging applications in enzyme catalysis, mass transfer, and metabolic engineering. Finally, we discuss the current challenges and future directions in the field, offering a conceptual and technical framework for the rational design of protein-based artificial organelles.

Identifiers

PMID41245762
PMCPMC12617375

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.