ArticleResearch in pharmaceutical sciences2025
Catechin hydrate prevents cadmium-induced collagen downregulation in mesenchymal stem cells
Article in Research in pharmaceutical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background and purpose: Cadmium (Cd) inhibited osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), while catechin hydrate (CH) improved the osteo-differentiation. Meanwhile, this investigation aimed to study the compensating effect of CH on Cd inhibition. Experimental approach: BMSCs from Wistar rats were treated with Cd and CH, and then the viability and population doubling number were investigated. Based on them, 1.5 μM and 0.25 μM of Cd and CH were chosen, respectively. Following osteogenic induction, matrix production, expression of osteogenic-related genes, and expression of collagen-1 (COL1-A1) protein were analyzed. Moreover, the ability of CH to prevent Cd-induced oxidative stress, as well as the metabolic activity of the treated cells, was evaluated. Findings/Results: The selected concentration of CH significantly ameliorated Cd-induced inhibition of BMSCs osteo-differentiation through preventing oxidative stress and ameliorating gene expression. Indeed, CH in the co-treatment group significantly improved the expression of Conclusion and implications: CH prevented oxidative stress and counteracted the inhibitory effect of Cd on the osteogenic differentiation of BMSCs. Therefore, CH may be suggested to prevent Cd toxicity on bone.
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