Evidence map›Paper›PMID 41245869›Full record

ReviewFrontiers in neurology2025

Clinical advances in transcutaneous auricular vagus nerve stimulation for post-stroke disorders: state of the art and future perspectives.

Jifei Sun, Xuefei Li, Yuan Zhou, Hongwei Liu, Chenjie Ma, Chunbo Hao, Shuqing Liu, Jingxue Zhao, Xiaojian Zhang, Xue Xiao

Abstract readReview
In one paragraph

Review in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jifei Sun *Shunyi Hospital, Beijing Hospital of Traditional Chinese Medicine, Beijing, China.
Xuefei Li *Eye Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Yuan ZhouShunyi Hospital, Beijing Hospital of Traditional Chinese Medicine, Beijing, China.
Hongwei LiuShunyi Hospital, Beijing Hospital of Traditional Chinese Medicine, Beijing, China.
Chenjie MaShunyi Hospital, Beijing Hospital of Traditional Chinese Medicine, Beijing, China.
Chunbo HaoShunyi Hospital, Beijing Hospital of Traditional Chinese Medicine, Beijing, China.
Shuqing LiuShunyi Hospital, Beijing Hospital of Traditional Chinese Medicine, Beijing, China.
Jingxue ZhaoGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Xiaojian ZhangShunyi Hospital, Beijing Hospital of Traditional Chinese Medicine, Beijing, China.
Xue XiaoBeijing Tsinghua Changgung Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcutaneous auricular vagus nerve stimulation (taVNS) has emerged as a promising non-invasive neuromodulation therapy for post-stroke disorders. This review synthesizes current evidence on the clinical efficacy and underlying mechanisms of taVNS in addressing a spectrum of post-stroke disorders, including motor, sensory, neuropsychiatric, and cognitive impairments. By targeting the auricular branch of the vagus nerve, taVNS modulates central pathways involved in neuroplasticity, anti-inflammation, angiogenesis, and blood-brain barrier protection, offering a multifaceted approach to stroke rehabilitation. Clinical studies demonstrate its potential to enhance functional recovery and improve quality of life, supported by its favorable safety profile and patient compliance. However, challenges such as parameter standardization, mechanistic elucidation, and individualized protocols remain. Future research should focus on large-scale trials, mechanistic exploration, and technological innovations to optimize taVNS applications in stroke care.

Indexed as

neuromodulationneuroplasticitynon-invasive therapystroke rehabilitationtranscutaneous auricular vagus nerve stimulation

Identifiers

PMID41245869
PMCPMC12615202

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.