ArticleMetabolism open2025
Pharmacokinetics and metabolic effects of ketone monoester supplementation: The first simultaneous CKM and CGM study under normal diet and activities.
Article in Metabolism open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Assessing head injury risk and neuroprotective effect of ketone monoester supplementation in military airborne training.Physiological reports · 2026Trial
- Effect of Oral Ketone Body Intake on Human CD8Nutrients · 2026Article
- A narrative review of dietary patterns in cardiovascular-kidney-metabolic syndrome.Frontiers in nutrition · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exogenous ketone supplementation has gained attention for its potential health and performance benefits, yet its real-world pharmacokinetics and metabolic effects remain underexplored. This study investigated the pharmacokinetics of ketone monoester (KME) supplementation during normal diet and activities, leveraging simultaneous interstitial fluid (ISF) continuous ketone and glucose monitoring (CKM and CGM). In this single-group observational study, twenty healthy adults underwent a 10-day KME supplementation protocol following a 4-day baseline period. Weight-based KME dosing rapidly elevated ISF β-hydroxybutyrate (BHB) levels, peaking within 1 h and sustaining ketosis for approximately 5 h. Exploratory correlational analyses revealed a two-stage influence pattern: larger skeletal/adipose mass slowed and blunted peak BHB levels (
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.