ReviewCureus2025
Perioperative Glycaemic Control and Orthopaedic Outcomes: A Narrative Review of Evidence and Future Directions.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In orthopaedic surgery, diabetes mellitus (DM) is consistently associated with delayed fracture healing, non-union, implant failure, periprosthetic joint infection, and poorer postoperative recovery. Although strict perioperative glycaemic control has been shown to improve outcomes in general surgical populations, current national thresholds are largely extrapolated from non-orthopaedic data and focus primarily on cardiovascular and soft-tissue complications rather than bone biology. Existing recommendations from national guidelines vary and remain non-specific to orthopaedics. No consensus exists on optimal perioperative glucose or glycated haemoglobin (HbA1c) targets for elective orthopaedic interventions. This review evaluates current evidence linking perioperative glycaemic status to orthopaedic outcomes. Relevant literature, particularly focused on total joint arthroplasty (TJA), was identified through a comprehensive search of PubMed, MEDLINE, and Google Scholar. Evidence reviewed in this article suggests that perioperative hyperglycaemia, rather than HbA1c alone, is a stronger predictor of complications. Prospective studies are needed to assess preoperative HbA1c and perioperative glucose trajectories and their relationship with standardised outcomes. The potential harms of intensive control, such as hypoglycaemia and surgical delays, also require careful consideration. Additionally, randomised controlled trials (RCTs) comparing intensified versus standard glucose control protocols are required, with both efficacy and safety as endpoints. Defining evidence-based, orthopaedic-specific glycaemic thresholds is essential to reduce complications, enhance recovery, and improve long-term outcomes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.