ArticleFrontiers in public health2025
Global trends and inequalities in the burden of drug use disorders: a comprehensive analysis from 1990 to 2021 with future projections.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- An ERP-based study of the effects of music tempo on inhibitory control among male drug addicts with different levels of psychological resilience.BMC psychology · 2026Article
- Global substance use disorders burden from 1990 to 2021: post-COVID shifts and widening inequalities.Journal of global health · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
Background: Drug use disorders (DUDs) pose a major global health challenge, with limited comprehensive data across demographic and socioeconomic groups. Methods: Using data from the Global Burden of Disease (GBD) 2021, we analyzed disability-adjusted life years (DALYs), deaths, prevalence, and incidence of DUDs from 1990 to 2021, stratified by sex, age, country, and Socio-Demographic Index (SDI). Trends were assessed using Joinpoint regression analysis, while cross-inequalities were evaluated through the Slope Index of Inequality (SII) and Concentration Index (CI). Nordpred projected future burden. Results: From 1990 to 2021, DALYs increased by 14.7%. Males and individuals aged 25-29 experienced the highest burden. High-SDI countries recorded the greatest DALYs and deaths. The SII increased from 82.4 in 1990 to 289.24 in 2021, and the CI revealed a disproportionate concentration of DUDs burden in high-SDI countries. Projections suggest that by 2044, DALYs will rise by 12.9 million, mainly due to opioid use disorders. Conclusion: The global burden of DUDs has increased significantly with widening health inequalities across SDI levels. Targeted interventions, particularly addressing the opioid crisis, are essential to manage and mitigate future impacts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.