ReviewFrontiers in immunology2025
Flavonoids as Immunoregulators: Molecular Mechanisms in Regulating Immune Cells and Their Therapeutic Applications in Inflammatory Diseases.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- The Gut-Brain-Skin Axis: Systemic Effects of Functional Ingredients in Healthy Skin Aging.International journal of molecular sciences · 2026Review
- Natural Products as Nutritional Supplements in Human Disease Prevention and Management: From Molecular Mechanisms to Clinical Translation.Nutrients · 2026Review
- Qingfei Huatan Formula alleviates growth suppression and inflammation-driven metabolic dysregulation in avian infectious bronchitis virus-infected broilers.Poultry science · 2026Article
- Plant-Derived Compounds as Potential Sensitizers to Immunotherapy in Melanoma.International journal of molecular sciences · 2026Review
- Role of Fisetin in the Mammalian Reproductive System.Veterinary sciences · 2026Review
- Dietary Polyphenols (Flavonoids) Derived from Plants for Use in Therapeutic Health: Antioxidant Performance, ROS, Molecular Mechanisms, and Bioavailability Limitations.International journal of molecular sciences · 2026Review
- Apigenin Upregulates Regulatory B Cells, Suppresses Class Switch Recombination, and Restores Immune Homeostasis to Treat Autoimmune Arthritis and Sepsis.Drug design, development and therapy · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flavonoids are a vital class of dietary polyphenolic compounds that have attracted considerable attention owing to their powerful immunoregulatory and anti-inflammatory effects. This review summarizes recent advances in understanding the role of flavonoids in regulating immune cells and their therapeutic application in inflammatory diseases. We present an overview of the definition, classification, and dietary sources of flavonoids and detail their regulatory effects on multiple key immune cells, therapeutic potential of flavonoids in various inflammatory diseases, as well as discuss strategies to improve their bioavailability and targeting. Despite the promising immunoregulatory properties of flavonoids, their clinical utilization is impeded by issues such as low bioavailability, considerable interindividual variability, and the absence of high-quality randomized controlled trials. Future research needs to focus on elucidating the precise mechanisms of flavonoids, optimizing their pharmacokinetic properties, and conducting more standardized clinical trials to facilitate the transformation of these natural compounds into standardized immunomodulatory therapeutic agents.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.